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NCT04310852: Bone-Gun
Knee Osteoarthritis Treatment With Percutaneous Injections of Autologous Bone Marrow Concentrate
trial testing BioCue Concentration Kit in Knee Osteoarthritis in 25 participants. Status unknown.
30 September 2021
Quick facts
| Lead sponsor | Istituto Clinico Humanitas |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 25 |
| Start date | 6 June 2018 |
| Primary completion | 30 September 2021 |
| Estimated completion | 31 January 2022 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- BioCue Concentration Kit
Conditions studied
- Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
- Cartilage Degeneration — all drugs for Cartilage Degeneration →
Sponsor
Istituto Clinico Humanitas
Who can join
Adults 40 to 70, any sex, with Knee Osteoarthritis or Cartilage Degeneration. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Recently there has been a growing interest in the role of subchondral bone in knee arthritis, both in its etiology and evolution and in its clinical significance. It has now been widely demonstrated that changes in the subchondral bone can develop both as a cause and as a consequence of joint degeneration and it is now accepted in the scientific community that the presence of these changes is of clinical importance, causing pain and an inflammatory state that can contribute to the evolution of arthrosis arthropathy. Recently the use of mesenchymal cells obtained from the bone marrow has been proposed for the treatment of gonarthrosis by intra-articular injections. Even more recently, treatments have been studied and proposed for the treatment of the bone-cartilage interface in knees affected by osteoarthrosis, using autologous bone marrow concentrate, with promising results.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04310852
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Istituto Clinico Humanitas trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04310852 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istituto Clinico Humanitas
- Last refreshed: 17 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04310852.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing