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NCT04304001: TUNE-UP

Test Up Now Education Program

Completed NA Results posted Last updated 29 October 2024
What this trial tests

NA trial testing Community Health Advisor in Colorectal Cancer Screening in 115 participants. Completed in 12 February 2024.

Timeline
7 April 2021
Primary endpoint
12 February 2024
12 February 2024

Quick facts

Lead sponsorFlorida A&M University
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposescreening
Enrollment115
Start date7 April 2021
Primary completion12 February 2024
Estimated completion12 February 2024
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

Florida A&M University

Who can join

Adults 45 to 64, any sex, with Colorectal Cancer Screening. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants Up to Date on Colorectal Cancer Screening Primary · 12 months

The colorectal cancer screening measure asks about completion of colonoscopy and blood stool tests. These tests are described prior to questions about completion of each test. The first question asks when was the most recent stool blood test (\> 1 year but \< 2 years ago; \> 2 years but not more than 5 years ago; or \> 5 years). The second question asks when was the most recent colonoscopy (a year ago or less; \> 1 year but \< 5 years ago; \> 5 years but not more than 10 years ago; or \> 10 years). Colorectal cancer screening receipt will be determined based on self-report and chart review to

GroupValue95% CI
Community Health Advisor29
Usual Care31
Colorectal Cancer Screening Knowledge Measure Secondary · 12 months

Participants are asked four multiple choice questions and 10 True/False questions to test knowledge about colorectal cancer and colorectal cancer screening. The range of the scale is 0-14. Each answer is scored as correct or incorrect. A score of 11 to 14 is considered "high". A score of 7 to 10 is considered "average". A score less than 7 is considered "low."

GroupValue95% CI
Community Health Advisor10.42± 2.01
Usual Care9.88± 1.61
Colorectal Cancer Screening Self-Efficacy Scale Secondary · 12 months

A validated 4-item measure of colorectal cancer screening self-efficacy (alpha = 0.82) asks participants to respond using a Likert scale about colorectal cancer screening test difficulty, finding time, ease of completing the test, and scheduling the test. Total scale scores range from 1 to 4. A score of 3 to 4 is considered "low self-efficacy" and a score of 1 to 2 is considered "high self-efficacy."

GroupValue95% CI
Community Health Advisor1.86± 0.56
Usual Care1.98± 0.61

Sponsor's own description

This study will test the effectiveness of an outreach strategy to increase colorectal cancer screening in African Americans. The investigators will recruit 250 African Americans ages 45-64 years who are not up-to-date with colorectal cancer screening or have never been screened, with the goal to evaluate screening knowledge, behavior, and intervention effects on colorectal cancer screening outcomes. Participants will be randomly assigned to the TUNE-UP intervention or a control group. The TUNE-UP intervention arm will utilize a community health advisor to encourage return of stool blood testing kits through cell phone outreach. The control group will receive educational materials about colorectal cancer screening plus a resource list but no community health advisor counseling support or cellphone / text contact. The primary study outcome is receipt of colorectal cancer screening (colonoscopy or Fecal Immunochemical Test) following the intervention. The secondary outcomes will include colorectal cancer screening knowledge, self-efficacy (confidence to receive colorectal cancer screening), intention to screen, and follow-up in the case of an abnormal test result. The research objective is to test the community health advisor intervention effectiveness for promoting stool blood testing as a preferred screening test in an under-screened African American population.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Association of Preventive Care Attitudes and Beliefs with Colorectal Cancer Screening History among African American Patients of Community Health Centers.
    Luque JS, Kiros GE, Vargas M, Jackson DR, et al · · 2023 · cited 3× · PMID 37442915 · DOI 10.1007/s13187-023-02337-1
  2. Assessing the effectiveness of a community health advisor plus screen to save educational intervention on stool-based testing adherence in an African American safety net clinic population: study protocol for a randomized pragmatic trial.
    Luque JS, Matthew OO, Jackson DR, Vargas MA, et al · · 2022 · cited 3× · PMID 35168640 · DOI 10.1186/s13063-022-06076-4
  3. Effectiveness of a community health advisor colorectal cancer screening educational intervention on stool test completion in an African American primary care patient population: a pragmatic randomized controlled trial.
    Luque JS, Kiros GE, Vargas MA, Ali A, et al · · 2025 · cited 2× · PMID 40450376 · DOI 10.1186/s44263-025-00168-4
  4. Current Progress in Clinical Research in Secondary Prevention and Early Detection of Colorectal Cancer.
    Partyka O, Pajewska M, Czerw A, Deptała A, et al · · 2025 · cited 2× · PMID 39941735 · DOI 10.3390/cancers17030367
  5. Monitoring of Colorectal Cancer Screening Adherence Among African American Patients of North Florida Community Health Centers.
    Luque JS, Kiros GE, Ali AA, Dickey SL, et al · · 2025 · PMID 41134442 · DOI 10.1007/s13187-025-02738-4

Verify or expand the search:

Other recruiting trials for Colorectal Cancer Screening

Currently open trials in the same condition.

Other Florida A&M University trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04304001.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing