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NCT04303494
Predictive Value of Heart Rate Variability on Cardiorespiratory Events
trial testing immunisation in Post-immunisation Apnoea and Bradycardia of Prematurity (AOP) in 292 participants. Completed in 5 November 2022.
5 November 2022
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 292 |
| Start date | 1 July 2018 |
| Primary completion | 5 November 2022 |
| Estimated completion | 5 November 2022 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- immunisation — full drug profile →
Conditions studied
- Post-immunisation Apnoea and Bradycardia of Prematurity (AOP) — all drugs for Post-immunisation Apnoea and Bradycardia of Prematurity (AOP) →
Sponsor
University Hospital, Basel, Switzerland
Who can join
Adults 3 Days to 28 Days, any sex, with Post-immunisation Apnoea and Bradycardia of Prematurity (AOP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study are to investigate whether heart rate variability (HRV) parameters derived from nonlinear time series analysis at five different time points have prognostic utility for assessing the risk of postimmunisation AOP in very preterm/very low birth weight infants immunised in the hospital.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Sample entropy of oxygen saturation in preterm infants.
Ramin-Wright L, Kaempfen S, Delgado-Eckert E, Sanchez C, et al · · 2025 · cited 1× · PMID 39972007 · DOI 10.1038/s41598-025-89174-y -
Heart Rate Variability Does Not Predict Recurrence of Apnoea of Prematurity After Ceasing Caffeine Therapy: A Prospective Cohort Study.
Kaempfen S, Hug M, Sanchez C, Delgado-Eckert E, et al · · 2025 · cited 1× · PMID 39805735 · DOI 10.1111/apa.17579 -
Association of Heart Rate Variability with Postnatal Maturation in Preterm Infants.
Kaempfen S, Sanchez C, Delgado-Eckert E, Schulzke SM. · · 2025 · PMID 40652921 · DOI 10.1159/000547287
Verify or expand the search:
- PubMed search for NCT04303494
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04303494 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 3 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04303494.
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