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NCT04297475
The Clinical Feasibilityof a Multi-modal Photoacoustic/Ultrasonic Imaging System in Rheumatoid Arthritis
trial testing Multi-modal photoacoustic/ultrasonic (PA/US) imaging system in Rheumatoid Arthritis in 200 participants. Status unknown.
31 December 2021
Quick facts
| Lead sponsor | Peking Union Medical College Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 1 January 2019 |
| Primary completion | 31 December 2021 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across China |
Drugs / interventions tested
- Multi-modal photoacoustic/ultrasonic (PA/US) imaging system
Conditions studied
- Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →
- Ultrasonography — all drugs for Ultrasonography →
Sponsor
Peking Union Medical College Hospital
Who can join
Eligibility, any sex, with Rheumatoid Arthritis or Ultrasonography. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
New type of imaging method is in demand clinically for early detection and treatment guiding of RA. Photoacoustic imaging (PAI), a hot spot in medical imaging society, which combines the merits of optical imaging and US and has a capacity in morphological, functional and molecular imaging, has shown potential in visualizing superficial organs, including small joints. The investigators developed a multi-modal photoacoustic/ultrasound (PA/US) imaging system, equipped with a handheld 3D PA/US probe, which wass able to provide 3D volume data of dual-wavelength PA imaging of small joints, in addition to real-time 2D PA/US imaging. The investigators plan to recruit RA patients in different disease conditions and healthy volunteers to receive the 2D and 3D PA/US examination on the 2nd and 3rd MCP, PIP joints and wrist joints using this imaging system, and to evaluate the potential clinical role of the imaging system in RA, and its added value to current imaging methods.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Synovial Oxygenation at Photoacoustic Imaging to Assess Rheumatoid Arthritis Disease Activity.
Yang M, Zhao C, Wang M, Wang Q, et al · · 2023 · cited 26× · PMID 35997608 · DOI 10.1148/radiol.212257 -
RATING: Medical knowledge-guided rheumatoid arthritis assessment from multimodal ultrasound images via deep learning.
Zhou Z, Zhao C, Qiao H, Wang M, et al · · 2022 · cited 5× · PMID 36277816 · DOI 10.1016/j.patter.2022.100592
Verify or expand the search:
- PubMed search for NCT04297475
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Rheumatoid Arthritis
Currently open trials in the same condition.
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Other Peking Union Medical College Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04297475 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Peking Union Medical College Hospital
- Last refreshed: 28 October 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04297475.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing