NCT04296643 is a Phase 4 clinical trial of Medical Mask in Coronavirus, sponsored by McMaster University.

Who is sponsoring NCT04296643?

NCT04296643 is sponsored by McMaster University.

What drugs are being tested in NCT04296643?

Interventions in NCT04296643: Medical Mask, N95 respirator.

What condition does NCT04296643 study?

NCT04296643 studies Coronavirus, N95, Medical Mask.

Is NCT04296643 still recruiting?

NCT04296643 is currently completed. Last updated 12 January 2023.

Last reviewed 2023-01-12 · How we verify

NCT04296643

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Medical Masks vs N95 Respirators for COVID-19

Completed Phase 4 Last updated 12 January 2023

What this trial tests

Phase 4 trial testing Medical Mask in Coronavirus in 1,009 participants. Completed in 8 December 2022.

Timeline

1 March 2020

Primary endpoint
1 June 2022

8 December 2022

Quick facts

Lead sponsor	McMaster University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	1,009
Start date	1 March 2020
Primary completion	1 June 2022
Estimated completion	8 December 2022
Sites	15 locations across Pakistan, Canada, Israel, Egypt

Drugs / interventions tested

Medical Mask
N95 respirator

Conditions studied

Coronavirus — all drugs for Coronavirus →
N95 — all drugs for N95 →
Medical Mask — all drugs for Medical Mask →

Sponsor

McMaster University

Who can join

18 and older, any sex, with Coronavirus or N95. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A randomized controlled trial in which health care workers will be randomized to either medical masks or N95 respirators when providing care to patients with COVID-19.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis.
Chu DK, Akl EA, Duda S, Solo K, et al · · 2020 · cited 2415× · PMID 32497510 · DOI 10.1016/s0140-6736(20)31142-9
Ongoing Clinical Trials for the Management of the COVID-19 Pandemic.
Lythgoe MP, Middleton P. · · 2020 · cited 247× · PMID 32291112 · DOI 10.1016/j.tips.2020.03.006
Physical interventions to interrupt or reduce the spread of respiratory viruses.
Jefferson T, Del Mar CB, Dooley L, Ferroni E, et al · · 2020 · cited 184× · PMID 33215698 · DOI 10.1002/14651858.cd006207.pub5
Physical interventions to interrupt or reduce the spread of respiratory viruses.
Jefferson T, Dooley L, Ferroni E, Al-Ansary LA, et al · · 2023 · cited 148× · PMID 36715243 · DOI 10.1002/14651858.cd006207.pub6
Medical masks and Respirators for the Protection of Healthcare Workers from SARS-CoV-2 and other viruses.
Ippolito M, Vitale F, Accurso G, Iozzo P, et al · · 2020 · cited 106× · PMID 32362505 · DOI 10.1016/j.pulmoe.2020.04.009
Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers : A Randomized Trial.
Loeb M, Bartholomew A, Hashmi M, Tarhuni W, et al · · 2022 · cited 54× · PMID 36442064 · DOI 10.7326/m22-1966
Use of facemasks during the COVID-19 pandemic.
Schünemann HJ, Akl EA, Chou R, Chu DK, et al · · 2020 · cited 45× · PMID 32758441 · DOI 10.1016/s2213-2600(20)30352-0
Randomized trials on non-pharmaceutical interventions for COVID-19: a scoping review.
Hirt J, Janiaud P, Hemkens LG. · · 2022 · cited 24× · PMID 35086864 · DOI 10.1136/bmjebm-2021-111825

Verify or expand the search:

Other recruiting trials for Coronavirus

Currently open trials in the same condition.

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NCT04376034 — Convalescent Plasma Collection and Treatment in Pediatrics and Adults · Phase 3 · recruiting
NCT04568148 — COVID-19 Biorepository · active not recruiting

Other McMaster University trials

Trials by the same sponsor.

NCT06231069 — Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults · NA · withdrawn
NCT07213492 — Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder · NA · recruiting
NCT07486505 — Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, M · NA · not yet recruiting
NCT07408128 — Partner4Exercise Randomized Controlled Trial · Phase 2, PHASE3 · not yet recruiting
NCT07459777 — Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anteri · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04296643 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by McMaster University
Last refreshed: 12 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04296643.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing