NCT04292873

Effects of Enteral Supplement Vitamin D Incritically Ill Patients

Completed NA Last updated 5 December 2023

What this trial tests

NA trial testing Vitamin D supplement in Vitamin D Deficiency in 61 participants. Completed in 31 March 2023.

Timeline

16 March 2020

Primary endpoint
26 December 2022

31 March 2023

Quick facts

Lead sponsor	National Taiwan University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	61
Start date	16 March 2020
Primary completion	26 December 2022
Estimated completion	31 March 2023
Sites	1 location across Taiwan

Drugs / interventions tested

• Vitamin D supplement — full drug profile →

Conditions studied

• Vitamin D Deficiency — all drugs for Vitamin D Deficiency →
• Critical Illness — all drugs for Critical Illness →

Sponsor

National Taiwan University Hospital

Who can join

20 and older, any sex, with Vitamin D Deficiency or Critical Illness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

At present, there is no clinical reference data on how much the concentration of calcifediol in the blood increases after supplementing with vitamin D for Taiwanese ICU patients. This study aims to investigate the effects of enteral supplementation of vitamin D in critically ill patients with vitamin D deficiency. The results of the study are expected to provide clinical reference data to intensivists to select adequate dosage of vitamin D supplementation for their patients with vitamin D deficiency.

This is a multi-center, randomized clinical trial. ICU patients will receive vitamin D level examination. If the subject's blood calcifediol concentration is less than 20 ng / mL, the subject will be included in this clinical trial. Patients who are suitable to enteral supplement of vitamin D will be randomly divided to group Control (no vitamin D supplement) and group Vitamin D (enteral supplement of 569,600 IU vitamin D). The vitamin D level will be measures at specific time points.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. ESICM LIVES 2022: part 2.
   · 2022 · cited 3× · PMID 36258052 · DOI 10.1186/s40635-022-00469-0
2. Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency.
   Wang AY, Yeh YC, Cheng KH, Han YY, et al · · 2025 · cited 2× · PMID 38729818 · DOI 10.1016/j.jfma.2024.05.005