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NCT04292197
A Study to Assess 18-Methoxycoronaridine (18-MC HCl) in Healthy Volunteers
Phase 1 trial testing 18-MC Compound in Addiction in 108 participants. Completed in 31 December 2021.
13 December 2021
Quick facts
| Lead sponsor | Definium Therapeutics US, Inc. |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 108 |
| Start date | 14 April 2020 |
| Primary completion | 13 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across Australia |
Drugs / interventions tested
- 18-MC Compound — full drug profile →
Conditions studied
- Addiction — all drugs for Addiction →
Sponsor
Definium Therapeutics US, Inc. — full company profile →
Who can join
Adults 18 to 55, any sex, with Addiction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of this study is to assess the safety and tolerability of a single day dosing and a separate multiple day dosing of 18-MC HCl administered orally, each part of the study having a different set of healthy male and female volunteers.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Old Dog, New Tricks: Ibogaine and Its Analogs as Potential Neurotherapeutics.
Ali S, Tian X, Cunningham KA, Zhou J. · · 2025 · cited 1× · PMID 40994282 · DOI 10.1021/acs.jmedchem.5c02510
Verify or expand the search:
- PubMed search for NCT04292197
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Definium Therapeutics US, Inc. trials
Trials by the same sponsor.
- NCT05407064 — A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms · Phase 2 · completed
- NCT05200936 — Safety and Efficacy of Low Dose MM120 for ADHD Proof of Concept Trial · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04292197 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Definium Therapeutics US, Inc.
- Last refreshed: 5 January 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04292197.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing