Who is sponsoring NCT04291976?

NCT04291976 is sponsored by Radboud University Medical Center.

What drugs are being tested in NCT04291976?

Interventions in NCT04291976: Back-to-back high-definition white light endoscopy, single-pass high-definition white light endoscopy, chromoendoscopy.

What condition does NCT04291976 study?

NCT04291976 studies Inflammatory Bowel Diseases, Colorectal Neoplasms.

Is NCT04291976 still recruiting?

NCT04291976 is currently completed. Last updated 21 November 2023.

Last reviewed 2023-11-21 · How we verify

NCT04291976: HELIOS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Back-to-back Endoscopy Versus Single-pass Endoscopy and Chromoendoscopy in IBD Surveillance

Completed NA Last updated 21 November 2023

What this trial tests

NA trial testing Back-to-back high-definition white light endoscopy in Inflammatory Bowel Diseases in 563 participants. Completed in 7 November 2023.

Timeline

13 March 2020

Primary endpoint
23 May 2023

7 November 2023

Quick facts

Lead sponsor	Radboud University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	563
Start date	13 March 2020
Primary completion	23 May 2023
Estimated completion	7 November 2023
Sites	4 locations across Netherlands

Drugs / interventions tested

Back-to-back high-definition white light endoscopy
single-pass high-definition white light endoscopy
chromoendoscopy

Conditions studied

Inflammatory Bowel Diseases — all drugs for Inflammatory Bowel Diseases →
Colorectal Neoplasms — all drugs for Colorectal Neoplasms →

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Inflammatory Bowel Diseases or Colorectal Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The current international guidelines for CRC surveillance in IBD recommend as first choice the use of chromoendoscopy, and as an alternative high-definition white light endoscopy (HDWLE) for optimal dysplasia detection, based on data from clinical trials. However, data on the superiority of CE over HDWLE are not consistent in literature. The investigators hypothesize that the better performance of CE in some clinical trials is the result of the associated longer procedural time and the fact that every colon segment is examined twice. Currently, no studies have been published evaluating the dysplastic yield of back-to back HDWLE compared to HDWLE with a single pass or CE in patients with IBD. In the present study, the investigators aim to compare the yield of dysplasia/CRC between 1) regular HDWLE, 2) HDWLE back-to-back, and 3) CE.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Inflammatory Bowel Disease and Colorectal Cancer.
Fanizza J, Bencardino S, Allocca M, Furfaro F, et al · · 2024 · cited 32× · PMID 39272800 · DOI 10.3390/cancers16172943

Verify or expand the search:

Other recruiting trials for Inflammatory Bowel Diseases

Currently open trials in the same condition.

NCT07520747 — A Database Study of Disease, Treatment Patterns and Healthcare Use in Children With Inflammatory Bowel Diseases in Korea · recruiting
NCT07349472 — Pentoxifylline in Patients With Ulcerative Colitis · Phase 2 · recruiting
NCT07033208 — Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance · NA · recruiting
NCT06842316 — Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases · recruiting
NCT06453317 — Comparison of Ustekinumab, Infliximab and Combination Therapy in Moderately to Severely Active Ulcerative Colitis · Phase 2 · recruiting

Other Radboud University Medical Center trials

Trials by the same sponsor.

NCT07485569 — Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial · Phase 1 · not yet recruiting
NCT07514325 — MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer · NA · not yet recruiting
NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04291976 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
Last refreshed: 21 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04291976.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing