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NCT04291118
Assessing Improvement in Cognitive Deficit in CRS in Patients Treated With Medical Vs Surgical Management
NA trial testing Private system endoscopic sinus surgery in Chronic Sinusitis in 150 participants. Status unknown.
1 September 2021
Quick facts
| Lead sponsor | St. Paul's Hospital, Canada |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | other |
| Enrollment | 150 |
| Start date | 10 February 2020 |
| Primary completion | 1 September 2021 |
| Estimated completion | 1 October 2021 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Private system endoscopic sinus surgery
- Public system endoscopic sinus surgery
- Budesonide (BUDESONIDE) — full drug profile →
Conditions studied
- Chronic Sinusitis — all drugs for Chronic Sinusitis →
Sponsor
St. Paul's Hospital, Canada
Who can join
20 and older, any sex, with Chronic Sinusitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic rhinosinusitis presents with a plethora of symptoms including non-rhinologic symptoms such as depression, sleep disturbances \& the more recently recognized cognitive dysfunction. It has recently been identified that sinus specific treatments such as endoscopic sinus surgery can improve cognitive outcomes in patients with cognitive deficit secondary to chronic inflammation in the upper and lower airway. However, it remains to be seen whether or not offering surgery to these patients at an earlier date has an impact on the degree of improvement on cognitive function in comparison to patients who have to wait long periods for their treatment.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04291118
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other St. Paul's Hospital, Canada trials
Trials by the same sponsor.
- NCT06750302 — Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial · Phase 1, PHASE2 · recruiting
- NCT06570590 — Prospective Study of Minimally Invasive Lapidus Procedure for Hallux Valgus Deformities · NA · not yet recruiting
- NCT05006287 — The Safety of Non-vitamin K Oral Anticoagulants Compared to Warfarin Early After Cardiac Surgery · Phase 2 · active not recruiting
- NCT04476628 — Efficacy of Budesonide Via Delayed Release vs Immediate Release · EARLY_PHASE1 · withdrawn
- NCT04449965 — Povidone-Iodine Rinses in the Management of COVID-19 · EARLY_PHASE1 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04291118 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by St. Paul's Hospital, Canada
- Last refreshed: 2 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04291118.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing