NCT04288700 is a Phase 4 clinical trial of oral propranolol in Infantile Hemangioma, sponsored by Ain Shams University.

Who is sponsoring NCT04288700?

NCT04288700 is sponsored by Ain Shams University.

What drugs are being tested in NCT04288700?

Interventions in NCT04288700: oral propranolol, Oral Captopril, intralesional propranolol injection, topical Timolol maleate 0.5% eye drops.

What condition does NCT04288700 study?

NCT04288700 studies Infantile Hemangioma.

Is NCT04288700 still recruiting?

NCT04288700 is currently status unknown. Last updated 28 February 2020.

Last reviewed 2020-02-28 · How we verify

NCT04288700

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma

Status unknown Phase 4 Last updated 28 February 2020

What this trial tests

Phase 4 trial testing oral propranolol in Infantile Hemangioma in 100 participants. Status unknown.

Timeline

1 October 2019

Primary endpoint
1 December 2020

1 October 2021

Quick facts

Lead sponsor	Ain Shams University
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	100
Start date	1 October 2019
Primary completion	1 December 2020
Estimated completion	1 October 2021
Sites	1 location across Egypt

Drugs / interventions tested

oral propranolol — full drug profile →
Oral Captopril — full drug profile →
intralesional propranolol injection — full drug profile →
topical Timolol maleate 0.5% eye drops — full drug profile →

Conditions studied

Infantile Hemangioma — all drugs for Infantile Hemangioma →

Sponsor

Ain Shams University

Who can join

Adults 2 Months to 12, any sex, with Infantile Hemangioma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Is to compare and evaluate the efficacy of oral captopril with oral propranolol, intralesional propranolol injection, and topical Timolol in the treatment of infantile hemangioma and their effect on vascular endothelial growth factor and CD 133.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions.
Fu L, Jin W, Zhang J, Zhu L, et al · · 2022 · cited 47× · PMID 35256933 · DOI 10.1016/j.apsb.2021.09.006
The role of the renin-angiotensin system inhibitors in malignancy: a review.
Yang J, Yang X, Gao L, Zhang J, et al · · 2021 · cited 21× · PMID 33791161
Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors.
Liu L, Yu J, Liu Y, Xie L, et al · · 2025 · cited 6× · PMID 40443737 · DOI 10.3389/fcell.2025.1572909

Verify or expand the search:

Other recruiting trials for Infantile Hemangioma

Currently open trials in the same condition.

NCT06798363 — Efficacy and Safety of Different Initial Doses of Oral Propranolol in the Treatment of Ulcerated Infantile Hemangioma · Phase 2, PHASE3 · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04288700 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 28 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04288700.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing