Who is sponsoring NCT04286321?

NCT04286321 is sponsored by Ohio State University.

What drugs are being tested in NCT04286321?

Interventions in NCT04286321: Zero hard-boiled egg at 0 h, One hard-boiled egg at 0 h, Two hard-boiled eggs at 0 h, Three hard-boiled eggs at 0 h, One hard-boiled egg at 3 h, One hard-boiled egg at 0 h + One hard-boiled egg at 3 h, Two egg whites at 0 h, Vegetable oil at 0 h.

What condition does NCT04286321 study?

NCT04286321 studies Nutritional Requirements.

Is NCT04286321 still recruiting?

NCT04286321 is currently completed. Last updated 3 June 2025.

Last reviewed 2025-06-03 · How we verify

NCT04286321

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Achieving Nutritional Adequacy Of Vitamin K With An Egg/Plant-Based Food Pairing

Completed NA Last updated 3 June 2025

What this trial tests

NA trial testing Zero hard-boiled egg at 0 h in Nutritional Requirements in 10 participants. Completed in 15 July 2024.

Timeline

1 June 2021

Primary endpoint
15 July 2024

15 July 2024

Quick facts

Lead sponsor	Ohio State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	10
Start date	1 June 2021
Primary completion	15 July 2024
Estimated completion	15 July 2024
Sites	1 location across United States

Drugs / interventions tested

Zero hard-boiled egg at 0 h
One hard-boiled egg at 0 h
Two hard-boiled eggs at 0 h
Three hard-boiled eggs at 0 h
One hard-boiled egg at 3 h
One hard-boiled egg at 0 h + One hard-boiled egg at 3 h
Two egg whites at 0 h
Vegetable oil at 0 h

Conditions studied

Nutritional Requirements — all drugs for Nutritional Requirements →

Sponsor

Ohio State University

Who can join

Adults 18 to 65, any sex, with Nutritional Requirements. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Malnutrition of the fat-soluble nutrient vitamin K (phylloquinone; PQ) is problematic. Since PQ is rich in plant foods (e.g. spinach) that are mostly absent of accessible lipid, dietary patterns that can potentiate PQ bioavailability by pairing vegetables with lipid-rich foods have been emphasized. The purpose of this study is to use deuterium-labeled spinach (containing stable isotopes of PQ) to validate eggs as a dietary tool to improve PQ bioavailability directly from a model plant food, and hence achieve nutrient adequacy. It is expected that compared with deuterium-labeled spinach alone, co-ingestion of eggs will increase plasma bioavailability of spinach-derived deuterium-labeled PQ without affecting time to maximal concentrations or half-lives. Further, phospholipid-rich egg yolk lipid will enhance nutrient bioavailability compared with vegetable oil. The outcomes will serve as the foundation for easy-to-implement message of public health importance in support of whole eggs and egg whites as part of a plant-based dietary pattern.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Zero hard-boiled egg at 0 h

Trials testing the same drug.

NCT04287816 — Achieving Nutritional Adequacy Of Vitamin E With An Egg/Plant-Based Food Pairing · NA · completed

Other recruiting trials for Nutritional Requirements

Currently open trials in the same condition.

NCT06074770 — Study on Dietary Intake Levels of Iodine for 3-6 Years Old Pre-school Children · recruiting

Other Ohio State University trials

Trials by the same sponsor.

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NCT07217548 — Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients · NA · enrolling by invitation
NCT07215221 — Implementation of TBI-RECOVER in Substance Use Treatment · NA · not yet recruiting
NCT07278427 — Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START · recruiting
NCT07490444 — Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04286321 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ohio State University
Last refreshed: 3 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04286321.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing