Intravesical Antibiotic Instillations Versus Oral Suppression for the Treatment of Recurrent Urinary Tract Infections in Post-menopausal Women

NCT04285320 Phase 4 UNKNOWN

This is a research study that aims to determine if antibiotic bladder instillations (placing an antibiotic directly into the bladder) over several sessions at the office is a good option to prevent recurrent urinary tract infections, in comparison with oral suppression therapy (taking daily antibiotics in the form of pills by mouth). Oral antibiotic suppression therapy is currently the most common treatment route for recurrent urinary tract infections in post-menopausal women. The bladder antibiotic instillation may overcome the disadvantages of oral suppression therapy such as antibiotic resistance, certain side effects, and recurrence of infections after finishing the treatment course.

Details

Lead sponsor	Atlantic Health System
Phase	Phase 4
Status	UNKNOWN
Enrolment	100
Start date	2021-03
Completion	2023-04

Conditions

• Recurrent Urinary Tract Infection

Interventions

• Intravesical antibiotic instillation
• Antibiotic oral suppressive therapy

Primary outcomes

• The percentage of participants with urinary tract infections following treatment course — Assessed starting immediately after the treatment is completed for a total of 3 months.
  To compare the percentage of women developing urinary tract infections during the 3 months following treatment between the two groups.