NCT04283630

Nitrate and Vitamin C on Vascular Health Oxidative Stress

Completed NA Last updated 25 February 2020

What this trial tests

NA trial testing Dietary nitrate in the form of beetroot juice for all participnats in Endothelial Dysfunction in 23 participants. Completed in 13 December 2019.

Timeline

5 February 2018

Primary endpoint
15 September 2019

13 December 2019

Quick facts

Lead sponsor	David Travis Thomas
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	23
Start date	5 February 2018
Primary completion	15 September 2019
Estimated completion	13 December 2019
Sites	2 locations across United States

Drugs / interventions tested

• Dietary nitrate in the form of beetroot juice for all participnats
• Nature Made vitamin c 1000 mg
• Placebo

Conditions studied

• Endothelial Dysfunction — all drugs for Endothelial Dysfunction →

Sponsor

David Travis Thomas — full company profile →

Who can join

Adults 50 to 70, any sex, with Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to examine whether the co-administration of dietary nitrate combined with vitamin C for 4 weeks in patients at risk for CVD would yield robust effects on endothelial function using blood measures and a non-invasive technique (Peripheral Artery Tonometry) compared to dietary nitrate supplementation alone.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The effect of dietary nitrate and vitamin C on endothelial function, oxidative stress and blood lipids in untreated hypercholesterolemic subjects: A randomized double-blind crossover study.
   Basaqr R, Skleres M, Jayswal R, Thomas DT. · · 2021 · cited 21× · PMID 33115598 · DOI 10.1016/j.clnu.2020.10.012