Who is sponsoring NCT04279574?

NCT04279574 is sponsored by Solventum US LLC.

What drugs are being tested in NCT04279574?

Interventions in NCT04279574: Lithium disilicate onlays (IPS emaxCAD/Ivoclar), Chairside zirconia crowns (3M).

What condition does NCT04279574 study?

NCT04279574 studies Dental Cements, Caries,Dental.

Is NCT04279574 still recruiting?

NCT04279574 is currently completed. Last updated 24 March 2025.

Are results published for NCT04279574?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-03-24 · How we verify

NCT04279574

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Performance of Chairside CAD/CAM Restorations

Completed NA Results posted Last updated 24 March 2025

What this trial tests

NA trial testing Lithium disilicate onlays (IPS emaxCAD/Ivoclar) in Dental Cements in 58 participants. Completed in 22 May 2024.

Timeline

26 August 2020

Primary endpoint
22 May 2024

22 May 2024

Quick facts

Lead sponsor	Solventum US LLC
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	58
Start date	26 August 2020
Primary completion	22 May 2024
Estimated completion	22 May 2024
Sites	1 location across United States

Drugs / interventions tested

Lithium disilicate onlays (IPS emaxCAD/Ivoclar)
Chairside zirconia crowns (3M)

Conditions studied

Dental Cements — all drugs for Dental Cements →
Caries,Dental — all drugs for Caries,Dental →

Sponsor

Solventum US LLC — full company profile →

Who can join

Adults 18 to 89, any sex, with Dental Cements or Caries,Dental. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Retention Scores] Primary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Retention. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[5b.1 Restoration in place; 5b.5 Complete loss of restoration\] Functional property (retention) assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	37
CAD/CAM Crowns	39
CAD/CAM Onlays	2
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	36
CAD/CAM Crowns	38
CAD/CAM Onlays	2
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Material Fracture Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Material Fracture. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional properties assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	38
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Approximal Anatomical Contact Form - Mesial] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Approximal anatomical contact form - mesial. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional property assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	38
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	2
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	36
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	4
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	34
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	5
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	34
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	5
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	33
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	5
CAD/CAM Crowns	0

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Approximal Anatomical Contact Point - Mesial Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Approximal anatomical contact point - mesial. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional property assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	38
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	35
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	33
CAD/CAM Crowns	37
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	2
CAD/CAM Onlays	1
CAD/CAM Crowns	1

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	34
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	33
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Approximal Anatomical Contact Form - Distal Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Approximal Anatomical Contact Form - Distal. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional property assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	29
CAD/CAM Crowns	25
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	27
CAD/CAM Crowns	24
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	27
CAD/CAM Crowns	22
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	26
CAD/CAM Crowns	24
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	24
CAD/CAM Crowns	22
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Approximal Anatomical Contact Point - Distal Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Approximal Anatomical Contact Point - Distal. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional property assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	29
CAD/CAM Crowns	25
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	27
CAD/CAM Crowns	24
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	27
CAD/CAM Crowns	22
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	26
CAD/CAM Crowns	23
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	24
CAD/CAM Crowns	21
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	1

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Occlusal Contour and Wear Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Occlusal contour and wear. Evaluations according to FDI World Dental Federation critera (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional property assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	38
CAD/CAM Crowns	37
CAD/CAM Onlays	0
CAD/CAM Crowns	2
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Biologic Properties of Restorations (Onlays and Crowns) [Recurrence of Caries, Erosion, Abfraction Scores] Secondary · 3 years with assessments at 6 months, 1 year, 2 years, and 3 years

Recurrence of caries, erosion, abfraction. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Biological properties assessed by visual and/or tactile assessment by two independent examiners.\]

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	37
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

Functional Long-term Properties Clinical Performance of Restorations (Onlays and Crowns) [Marginal Adaptation Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Marginal Adaptation. Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Functional property assessed by visual and/or tactile assessment by two independent examiners.\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	31
CAD/CAM Crowns	31
CAD/CAM Onlays	9
CAD/CAM Crowns	9
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	20
CAD/CAM Crowns	14
CAD/CAM Onlays	19
CAD/CAM Crowns	25
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	12
CAD/CAM Crowns	9
CAD/CAM Onlays	27
CAD/CAM Crowns	31
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	1
CAD/CAM Crowns	11
CAD/CAM Onlays	37
CAD/CAM Crowns	28
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Esthetic Properties of Restorations (Onlays and Crowns) [Surface Luster Scores] Secondary · 3 years with assessment visits at baseline, 6 months, 1 year, 2 years, and 3 years

Surface Luster: Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\]

Baseline

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

6 months post-restoration

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	38
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Short-term Post-operative Sensitivity (Onlays and Crowns) Secondary · up to 4 weeks after baseline with weekly assessments or until the restoration is reported asymptomatic

Evaluations according to FDI World Dental Federation criteria (Hickel et al., 2010) \[Rating Scale 1: Clinically excellent, 2: Clinically good, 3: Clinically sufficient, 4: Clinically unsatisfactory, 5: Clinically poor\] Biological properties assessed by patient interview.

1 week post-restoration

Group	Value	95% CI
CAD/CAM Onlays	37
CAD/CAM Crowns	34
CAD/CAM Onlays	3
CAD/CAM Crowns	4
CAD/CAM Onlays	0
CAD/CAM Crowns	2
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 weeks post-restoration

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	37
CAD/CAM Onlays	0
CAD/CAM Crowns	2
CAD/CAM Onlays	0
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

3 weeks post-restoration

Group	Value	95% CI
CAD/CAM Onlays	0
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	40
CAD/CAM Crowns	0

Gingival Index (Onlays and Crowns) Secondary · 3 years with assessments at 6 months, 1 year, 2 years, and 3 years

Loe \& Silness Index, 1963 \[0: normal gingiva, 1: mild inflammation and no bleeding, 2: moderate inflammation and bleeding, 3: severe inflammation\]

6 months post-restporation

Group	Value	95% CI
CAD/CAM Onlays	40
CAD/CAM Crowns	40
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	0
CAD/CAM Crowns	0

1 year post-restoration

Group	Value	95% CI
CAD/CAM Onlays	38
CAD/CAM Crowns	38
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0

2 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	39
CAD/CAM Crowns	39
CAD/CAM Onlays	0
CAD/CAM Crowns	1
CAD/CAM Onlays	0
CAD/CAM Crowns	0
CAD/CAM Onlays	1
CAD/CAM Crowns	0

3 years post-restoration

Group	Value	95% CI
CAD/CAM Onlays	37
CAD/CAM Crowns	37
CAD/CAM Onlays	1
CAD/CAM Crowns	2
CAD/CAM Onlays	1
CAD/CAM Crowns	1
CAD/CAM Onlays	1
CAD/CAM Crowns	0

Adverse events — posted to ClinicalTrials.gov

Time frame: From participant's first treatment restoration to subject's completion of the study, an average of 3 years... Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

CAD/CAM Onlays

Serious: 1/35 (3%)

Deaths: 1/35

CAD/CAM Crowns

Serious: 0/33 (0%)

Deaths: 0/33

Serious adverse events (1 terms)

Reaction	System	CAD/CAM Onlays	CAD/CAM Crowns
Death	General disorders	—	—

Most-reported serious reactions: Death.

Data from ClinicalTrials.gov NCT04279574 adverse events section.

Sponsor's own description

This investigation will be a longitudinal clinical trial to study the long-term clinical performance of a resin cement for chairside CAD/CAM restorations. Lithium disilicate chairside CAD/CAM onlays will be adhesively bonded using a selective enamel etch technique with an adhesive. Full contour zirconia crowns will be cemented using a self-adhesive resin cement.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04279574 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Solventum US LLC
Last refreshed: 24 March 2025

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NCT04279574

Quick facts

Drugs / interventions tested

Conditions studied

Sponsor

Who can join

Results — posted to ClinicalTrials.gov

Adverse events — posted to ClinicalTrials.gov

Serious adverse events (1 terms)

Sponsor's own description

Publications & conference data

Related trials

Other Solventum US LLC trials

Verify against primary sources