Who is sponsoring NCT04277728?

NCT04277728 is sponsored by University Hospital Muenster.

What drugs are being tested in NCT04277728?

Interventions in NCT04277728: hypoperfusion-hypodensity mismatch.

What condition does NCT04277728 study?

NCT04277728 studies Acute Ischemic Stroke.

Is NCT04277728 still recruiting?

NCT04277728 is currently completed. Last updated 20 February 2020.

Last reviewed 2020-02-20 · How we verify

NCT04277728: MissPerfeCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hypoperfusion-hypodensity Mismatch for the Identification of Patients With Stroke Within 4.5 Hours

Completed Last updated 20 February 2020

What this trial tests

trial testing hypoperfusion-hypodensity mismatch in Acute Ischemic Stroke in 689 participants. Completed in 31 December 2019.

Timeline

1 January 2018

Primary endpoint
31 December 2019

31 December 2019

Quick facts

Lead sponsor	University Hospital Muenster
Status	Completed
Study type	OBSERVATIONAL
Enrollment	689
Start date	1 January 2018
Primary completion	31 December 2019
Estimated completion	31 December 2019
Sites	1 location across Germany

Drugs / interventions tested

hypoperfusion-hypodensity mismatch

Conditions studied

Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →

Sponsor

University Hospital Muenster

Who can join

18 and older, any sex, with Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Intravenous thrombolysis is recommended within 4.5 hours of stroke onset. The aim of the study is to evaluate whether a hypodensity on native CT within the virtually entire area of hypoperfusion on perfusion CT, i.e. hypoperfusion-hypodensity mismatch, identifies patients within the time window of thrombolysis in a multicenter cohort. The investigators hypothesize hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with \>70% specificity and \>85% positive predictive value.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

CT Hypoperfusion-Hypodensity Mismatch to Identify Patients With Acute Ischemic Stroke Within 4.5 Hours of Symptom Onset.
Sporns PB, Kemmling A, Minnerup H, Meyer L, et al · · 2021 · cited 9× · PMID 34649883 · DOI 10.1212/wnl.0000000000012891
Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study.
Sporns PB, Höhne M, Meyer L, Krogias C, et al · · 2022 · cited 3× · PMID 36221942 · DOI 10.5853/jos.2022.00220
Computed tomography hypoperfusion-hypodensity mismatch vs. automated perfusion mismatch to identify stroke patients eligible for thrombolysis.
Sporns PB, Kemmling A, Meyer L, Krogias C, et al · · 2023 · PMID 38225983 · DOI 10.3389/fneur.2023.1320620

Verify or expand the search:

Other recruiting trials for Acute Ischemic Stroke

Currently open trials in the same condition.

NCT07115940 — Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours · NA · recruiting
NCT07404852 — Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemi · NA · recruiting
NCT07361302 — A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Pe · Phase 3 · recruiting
NCT07436156 — SUMMIT RISE Study of Acute Ischemic Stroke Patients · Phase 4 · recruiting
NCT07203625 — Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours · Phase 4 · recruiting

Other University Hospital Muenster trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04277728 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Muenster
Last refreshed: 20 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04277728.

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