Last reviewed · How we verify
NCT04273750
RAI & HRS: Relationship Between Relative Adrenal Insufficiency and Failure of Treatment in Hepatorenal Syndrome
trial in Liver Cirrhosis in 26 participants. Completed in 5 February 2020.
5 February 2020
Quick facts
| Lead sponsor | University Hospital Plymouth NHS Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 26 |
| Start date | 5 March 2018 |
| Primary completion | 5 February 2020 |
| Estimated completion | 5 February 2020 |
| Sites | 1 location across United Kingdom |
Conditions studied
- Liver Cirrhosis — all drugs for Liver Cirrhosis →
- Acute Kidney Injury — all drugs for Acute Kidney Injury →
- Hepato-Renal Syndrome — all drugs for Hepato-Renal Syndrome →
Sponsor
University Hospital Plymouth NHS Trust
Who can join
Adults 18 to 80, any sex, with Liver Cirrhosis or Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hepatorenal syndrome is a life-threatening medical condition and a serious complication of advanced liver scarring (cirrhosis). It consists of a deterioration of the function of the kidneys caused by a severe alteration in the circulation (blood flow to the kidneys) due to liver cirrhosis. Only around half of the patients respond to treatment which consists of intravenous medication. Moreover, the adrenal glands, which are located on the kidneys, also suffer an alteration in the blood flow leading to deterioration in their function as well. Thus, these patients produced less cortisol than needed; this situation is called "relative adrenal insufficiency". Cortisol is an important hormone necessary in extreme situations such as severe diseases. This is a study which will assess the relationship between the presence of adrenal dysfunction and failure to treatment in patients with hepatorenal syndrome.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04273750
- Europe PMC full search
- ASCO Meeting Library
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04273750 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital Plymouth NHS Trust
- Last refreshed: 18 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04273750.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing