NCT04273321 is a NA clinical trial of Methylprednisolone in COVID-19, sponsored by Beijing Chao Yang Hospital.

Who is sponsoring NCT04273321?

NCT04273321 is sponsored by Beijing Chao Yang Hospital.

What drugs are being tested in NCT04273321?

Interventions in NCT04273321: Methylprednisolone.

What condition does NCT04273321 study?

NCT04273321 studies COVID-19, Novel Coronavirus Pneumonia.

Is NCT04273321 still recruiting?

NCT04273321 is currently completed. Last updated 11 May 2020.

Last reviewed 2020-05-11 · How we verify

NCT04273321

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy and Safety of Corticosteroids in COVID-19

Completed NA Last updated 11 May 2020

What this trial tests

NA trial testing Methylprednisolone in COVID-19 in 86 participants. Completed in 15 April 2020.

Timeline

14 February 2020

Primary endpoint
15 April 2020

15 April 2020

Quick facts

Lead sponsor	Beijing Chao Yang Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	86
Start date	14 February 2020
Primary completion	15 April 2020
Estimated completion	15 April 2020
Sites	7 locations across China

Drugs / interventions tested

Methylprednisolone (methylprednisolone) — full drug profile →

Conditions studied

COVID-19 — all drugs for COVID-19 →
Novel Coronavirus Pneumonia — all drugs for Novel Coronavirus Pneumonia →

Sponsor

Beijing Chao Yang Hospital

Who can join

18 and older, any sex, with COVID-19 or Novel Coronavirus Pneumonia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

There is still controversy about the effective of glucocorticoids for the treatment of novel coronavirus pneumonia. This is a prospective randomized controlled trails. The aim is to explore the effectiveness and safety of glucocorticoids in the treatment of novel coronavirus pneumonia.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

The trinity of COVID-19: immunity, inflammation and intervention.
Tay MZ, Poh CM, Rénia L, MacAry PA, et al · · 2020 · cited 2973× · PMID 32346093 · DOI 10.1038/s41577-020-0311-8
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.
WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC, Murthy S, Diaz JV, et al · · 2020 · cited 1746× · PMID 32876694 · DOI 10.1001/jama.2020.17023
Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic.
Driggin E, Madhavan MV, Bikdeli B, Chuich T, et al · · 2020 · cited 1272× · PMID 32201335 · DOI 10.1016/j.jacc.2020.03.031
COVID-19: Transmission, prevention, and potential therapeutic opportunities.
Lotfi M, Hamblin MR, Rezaei N. · · 2020 · cited 447× · PMID 32474009 · DOI 10.1016/j.cca.2020.05.044
A Review of SARS-CoV-2 and the Ongoing Clinical Trials.
Tu YF, Chien CS, Yarmishyn AA, Lin YY, et al · · 2020 · cited 406× · PMID 32290293 · DOI 10.3390/ijms21072657
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19).
Kakodkar P, Kaka N, Baig MN. · · 2020 · cited 255× · PMID 32269893 · DOI 10.7759/cureus.7560
Ongoing Clinical Trials for the Management of the COVID-19 Pandemic.
Lythgoe MP, Middleton P. · · 2020 · cited 247× · PMID 32291112 · DOI 10.1016/j.tips.2020.03.006
Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions.
Jafarzadeh A, Chauhan P, Saha B, Jafarzadeh S, et al · · 2020 · cited 246× · PMID 32687918 · DOI 10.1016/j.lfs.2020.118102

Verify or expand the search:

Other trials of Methylprednisolone

Trials testing the same drug.

NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
NCT07455396 — Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Ped · Phase 2 · not yet recruiting
NCT07507643 — A Study of Methylprednisolone in People Having Liver Surgery · Phase 3 · recruiting
NCT07357935 — Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced · Phase 1, PHASE2 · not yet recruiting
NCT07265258 — A Study of Teprotumumab N01 in Subjects With Active Thyroid Eye Disease · Phase 4 · not yet recruiting

Other recruiting trials for COVID-19

Currently open trials in the same condition.

NCT07183709 — Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults · Phase 1 · active not recruiting
NCT07300839 — A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age · Phase 3 · active not recruiting
NCT07221162 — A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes · Phase 1 · recruiting
NCT07215520 — Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults · Phase 2 · recruiting
NCT07222384 — A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That A · Phase 3 · active not recruiting

Other Beijing Chao Yang Hospital trials

Trials by the same sponsor.

NCT07520305 — Efficacy Heterogeneity of Lactobacillus Paracasei LC19 on Type 2 Diabetes · NA · not yet recruiting
NCT07490925 — Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS · NA · not yet recruiting
NCT07382986 — IMPACT COPD Cohort (China) · recruiting
NCT07323134 — The Effect of Semaglutide on the Intestinal Flora in Obesity · not yet recruiting
NCT07049692 — Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04273321 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Chao Yang Hospital
Last refreshed: 11 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04273321.

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