NCT04261452

Heart Failure Worsens Muscle Strength in COPD

Completed NA Last updated 7 February 2020

What this trial tests

NA trial testing isokinetic dynamometer in COPD in 50 participants. Completed in 1 December 2018.

Timeline

1 August 2014

Primary endpoint
1 December 2017

1 December 2018

Quick facts

Lead sponsor	Mayron Faria de Oliveira
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	factorial
Masking	none
Primary purpose	basic science
Enrollment	50
Start date	1 August 2014
Primary completion	1 December 2017
Estimated completion	1 December 2018

Drugs / interventions tested

• isokinetic dynamometer
• Cardiopulmonary Exercise Test
• Functional Capacity Tests
• Lung Function Test
• Doppler Echocardiography
• Anthropometry and Body Composition

Conditions studied

• COPD — all drugs for COPD →
• CHF — all drugs for CHF →
• Muscle Weakness — all drugs for Muscle Weakness →

Sponsor

Mayron Faria de Oliveira

Who can join

30 and older, any sex, with COPD or CHF. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The combination of heart failure (HF) and chronic obstructive pulmonary disease (COPD) is highly prevalent, but underdiagnosed and poorly recognized. It has been suggested that the decline in functional capacity is associated with musculoskeletal and systemic changes than primary organ (heart and/or lung) failure. In addition, it is recognized that both diseases have several mechanisms that are responsible for musculoskeletal impairment. However, the association of reduced systemic perfusion with low oxygen content observed in the association of HF and COPD may contribute to the worsening of the components of the muscle impairment cascade. Thus, muscle strength and fatigue may not only be even more altered but may also be the main determinants of functional capacity in patients with coexistence of HF and COPD. Although many studies have evaluated the muscle performance of patients with HF or COPD, the literature did not show data on worsening due to the association of the diseases. Particularities identification of the muscle impairment in the coexistence of HF and COPD is fundamental for the development of rehabilitation strategies, mainly through physical exercise. In this line, the present study tested the hypothesis that the coexistence of HF and COPD could present lower values of strength and greater fatigue. Similarly, the muscle dysfunction degree could strongly correlate with the performance markers of the incremental or functional tests in patients with HF associated with COPD.

The study protocol was reviewed and approved by the Institutional Research Board. All subjects gave written informed consent before participating in the study.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.