NCT04260724 is a NA clinical trial of TMS in Mild to Moderate Alzheimer Disease, sponsored by Samsung Medical Center.

Who is sponsoring NCT04260724?

NCT04260724 is sponsored by Samsung Medical Center.

What drugs are being tested in NCT04260724?

Interventions in NCT04260724: TMS, sham coil stimulation.

What condition does NCT04260724 study?

NCT04260724 studies Mild to Moderate Alzheimer Disease.

Is NCT04260724 still recruiting?

NCT04260724 is currently status unknown. Last updated 7 February 2020.

Last reviewed 2020-02-07 · How we verify

NCT04260724

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease

Status unknown NA Last updated 7 February 2020

What this trial tests

NA trial testing TMS in Mild to Moderate Alzheimer Disease in 32 participants. Status unknown.

Timeline

7 February 2020

Primary endpoint
7 February 2021

7 February 2022

Quick facts

Lead sponsor	Samsung Medical Center
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	32
Start date	7 February 2020
Primary completion	7 February 2021
Estimated completion	7 February 2022
Sites	1 location across South Korea

Drugs / interventions tested

TMS — full drug profile →
sham coil stimulation

Conditions studied

Mild to Moderate Alzheimer Disease — all drugs for Mild to Moderate Alzheimer Disease →

Sponsor

Samsung Medical Center

Who can join

Adults 55 to 90, any sex, with Mild to Moderate Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators will compare cognitition, mood (depression), ADL, and brain structural and functional MRI before and after 4-week transcranial magnetic stimulation in patients with mild to moderate Alzheimer's disease. The investigators also compare the change of cognitition, mood (depression), ADL, and brain structural and functional MRI between TMS group and sham coil group.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer's Disease.
Toniolo S, Sen A, Husain M. · · 2020 · cited 74× · PMID 33297460 · DOI 10.3390/ijms21239318
Therapy for Alzheimer's disease: Missing targets and functional markers?
Stoiljkovic M, Horvath TL, Hajós M. · · 2021 · cited 52× · PMID 33711510 · DOI 10.1016/j.arr.2021.101318
Effectiveness of Personalized Hippocampal Network-Targeted Stimulation in Alzheimer Disease: A Randomized Clinical Trial.
Jung YH, Jang H, Park S, Kim HJ, et al · · 2024 · cited 36× · PMID 38709534 · DOI 10.1001/jamanetworkopen.2024.9220
Effects of transcranial magnetic stimulation on neurobiological changes in Alzheimer's disease (Review).
Bashir S, Uzair M, Abualait T, Arshad M, et al · · 2022 · cited 22× · PMID 35119081 · DOI 10.3892/mmr.2022.12625
Diagnostic and inclusion criteria in Alzheimer's disease clinical trials: A systematic review of the past decade.
Liu Y, Chen S, Li S, Pei Z, et al · · 2025 · PMID 40755858 · DOI 10.1177/25424823251362444

Verify or expand the search:

Other trials of TMS

Trials testing the same drug.

NCT07346794 — The Underlying Neural Mechanism of TMS in Improving the Imbalance of "Microbiota-brain-gut Axis" in Alzheimer 's Disease · NA · not yet recruiting
NCT07290738 — Transcranial Magnetic Stimulation (TMS) for Negative Symptoms in Schizophrenia Spectrum Disorders · NA · recruiting
NCT07010614 — Brain Stimulation to the Hippocampus in Schizophrenia · NA · recruiting
NCT06274112 — Using TMS to Understand Neural Processes of Social Motivation · NA · recruiting
NCT07147218 — Accelerated TMS for MDD · NA · recruiting

Other Samsung Medical Center trials

Trials by the same sponsor.

NCT07482865 — Routine Versus Provisional Distal Perfusion Catheter Placement in Patients Undergoing Mechanical Circulatory Support · NA · not yet recruiting
NCT07467213 — Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute M · Phase 4 · not yet recruiting
NCT07530913 — Effectiveness Analysis of a Rehabilitation Exercise Platform for Living Donor Liver Transplantation Patients · NA · enrolling by invitation
NCT07500701 — Salvage Moderate Hypofractionated Versus Ultrahypofractionated Radiotherapy for Biochemical Recurrence After Radical Pro · Phase 3 · recruiting
NCT07409441 — Korea Acute Myocardial Infarction Registry · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04260724 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Samsung Medical Center
Last refreshed: 7 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04260724.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing