NCT04260165 (PROOF) is a NA clinical trial of Proximal Row Carpectomy in Wrist Osteoarthritis, sponsored by Töölö Hospital.

Who is sponsoring NCT04260165?

NCT04260165 is sponsored by Töölö Hospital.

What drugs are being tested in NCT04260165?

Interventions in NCT04260165: Proximal Row Carpectomy, Four-corner fusion.

What condition does NCT04260165 study?

NCT04260165 studies Wrist Osteoarthritis, Scapholunate Advanced Collapse.

Is NCT04260165 still recruiting?

NCT04260165 is currently recruiting now. Last updated 19 January 2021.

Last reviewed 2021-01-19 · How we verify

NCT04260165: PROOF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Proximal Row Carpectomy vs Four-corner Fusion for Osteoarthritis of the Wrist

Recruiting now NA Last updated 19 January 2021

What this trial tests

NA trial testing Proximal Row Carpectomy in Wrist Osteoarthritis in 84 participants. Currently enrolling.

Timeline

1 October 2020

Primary endpoint
31 December 2024

31 December 2034

Quick facts

Lead sponsor	Töölö Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	84
Start date	1 October 2020
Primary completion	31 December 2024
Estimated completion	31 December 2034
Sites	5 locations across Finland

Drugs / interventions tested

Proximal Row Carpectomy
Four-corner fusion

Conditions studied

Wrist Osteoarthritis — all drugs for Wrist Osteoarthritis →
Scapholunate Advanced Collapse — all drugs for Scapholunate Advanced Collapse →

Sponsor

Töölö Hospital

Who can join

Adults 18 to 75, any sex, with Wrist Osteoarthritis or Scapholunate Advanced Collapse. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study purpose is to compare the outcome after proximal row carpectomy (PRC) vs four-corner fusion (FCA) for SLAC/SNAC II-III type osteoarthritis (OA) in a double-blinded randomized controlled study setting. Patients with radiologically and clinically confirmed OA are randomized (1:1 computer generated sequence with random block size) to two parallel groups and will undergo either PRC or FCA. The study will be patient and assessor blinded. Baseline data is collected preoperatively and is followed by a follow-up visits at 2 and 6 weeks, 3, 6, 12 months, and 5, 10 years after the intervention. Unveiling of the allocation is at 12 months post-intervention.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Proximal ROw carpectOmy versus four-corner Fusion (PROOF-trial) for osteoarthritis of the wrist: study protocol for multi-institutional double-blinded randomized controlled trial.
Alanen M, Stjernberg-Salmela S, Waris E, Karjalainen T, et al · · 2023 · PMID 37550711 · DOI 10.1186/s13063-023-07544-1
Proximal ROw carpectOmy versus four-corner Fusion (PROOF-trial) for osteoarthritis of the wrist: Study protocol for multi-institutional double-blinded randomized controlled trial
Alanen M, Stjernberg-Salmela S, Waris E, Karjalainen T, et al · · 2022 · DOI 10.21203/rs.3.rs-2230205/v1

Verify or expand the search:

Other trials of Proximal Row Carpectomy

Trials testing the same drug.

NCT05412615 — PRC With Meniscal Allograft Arthroplasty for Wrist Osteoarthritis · NA · recruiting

Other recruiting trials for Wrist Osteoarthritis

Currently open trials in the same condition.

NCT06917235 — Wrist and Carpal Arthrodeses. A 1-year Follow-up Study. · recruiting
NCT05412615 — PRC With Meniscal Allograft Arthroplasty for Wrist Osteoarthritis · NA · recruiting

Other Töölö Hospital trials

Trials by the same sponsor.

NCT06365710 — Physiotherapy vs Telerehabilitation After Volar Plating of Distal Radius Fracture · NA · recruiting
NCT04403958 — The Use of Proximal Carpal Row Versus Iliac Crest as Bone Graft in Total Wrist Fusion · NA · unknown
NCT04826380 — Thumb Basal Joint (CMC I) Arthritis - Preoperative Anxiety/Depression, Outcome Instruments, Carpal Cinematics and Cost-u · NA · unknown
NCT04323410 — Casting Versus Percutaneus Pinning Treatment of Pediatric Overriding Distal Forearm Fractures · NA · recruiting
NCT04167098 — Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04260165 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Töölö Hospital
Last refreshed: 19 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04260165.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing