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NCT04258098
Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs: A Propensity Analysis
trial testing Oral antibiotics ( Streptomycin ,metronidazole ) in Surgical Site Infection in 806 participants. Completed in 12 May 2019.
31 December 2017
Quick facts
| Lead sponsor | Third Affiliated Hospital, Sun Yat-Sen University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 806 |
| Start date | 1 January 2011 |
| Primary completion | 31 December 2017 |
| Estimated completion | 12 May 2019 |
Drugs / interventions tested
- Oral antibiotics ( Streptomycin ,metronidazole ) — full drug profile →
Conditions studied
- Surgical Site Infection — all drugs for Surgical Site Infection →
- Colorectal Cancer — all drugs for Colorectal Cancer →
Sponsor
Third Affiliated Hospital, Sun Yat-Sen University
Who can join
Eligibility, any sex, with Surgical Site Infection or Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Surgical site infections (SSIs) are a major postoperative complication after colorectal surgery. Current study aims to evaluate prophylactic function of oral antibiotic intake (OA) in combination with mechanical bowel preparation (MBP) relative to MBP alone with respect to postoperative SSIs incidence. A retrospective analysis of eligible patients was to conducted using the databases of the Gastrointestinal Surgery Centre, Third Affiliated Hospital of Sun Yat-sen University from 2011 to 2017. Data pertaining to postoperative hospital stay length, expenses, SSIs incidence, anastomotic fistula incidence, and rates of other complications wloud be extracted and compared. A propensity analysis was conducted to minimize bias associated with demographic characteristics.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Preoperative mechanical bowel preparation with oral antibiotics reduces surgical site infection after elective colorectal surgery for malignancies: results of a propensity matching analysis.
Lei P, Ruan Y, Yang X, Wu J, et al · · 2020 · cited 12× · PMID 32046725 · DOI 10.1186/s12957-020-1804-4
Verify or expand the search:
- PubMed search for NCT04258098
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Third Affiliated Hospital, Sun Yat-Sen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04258098 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Third Affiliated Hospital, Sun Yat-Sen University
- Last refreshed: 6 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04258098.
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