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NCT04254484
SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation
NA trial testing SIESTA Rehab Education in Sleep in 400 participants. Completed in 14 July 2025.
15 May 2025
Quick facts
| Lead sponsor | University of Chicago |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 400 |
| Start date | 21 July 2020 |
| Primary completion | 15 May 2025 |
| Estimated completion | 14 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- SIESTA Rehab Education
- ApneaLink
Conditions studied
- Sleep — all drugs for Sleep →
- Sleep Disordered Breathing — all drugs for Sleep Disordered Breathing →
- Stroke — all drugs for Stroke →
Sponsor
University of Chicago
Who can join
18 and older, any sex, with Sleep or Sleep Disordered Breathing. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Given the critical role of sleep in enhancing neural recovery, motor learning, neuroprotection, and neuroplasticity, interventions to enhance sleep that target sleep could improve recovery and rehabilitation outcomes for stroke patients. In this proposal, a multidisciplinary group of researchers with expertise in rehabilitation medicine, sleep medicine, nursing, physical therapy, wearable technologies, and implementation science will adapt, implement and evaluate a state-of-the-art intervention to promote sleep for stroke patients undergoing acute rehabilitation. SIESTA-Rehab, adapted from a previous unit-based intervention, bundles two sleep-promoting interventions to address the unique sleep challenges stroke patients face during acute rehabilitation: (1) nursing education and empowerment to reduce unnecessary disruptions; (2) a systematic protocol to screen, diagnose, and treat sleep-disordered breathing if present during acute stroke rehabilitation.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Wireless wearable sensors can facilitate rapid detection of sleep apnea in hospitalized stroke patients.
Sindorf J, Szabo AL, O'Brien MK, Sunderrajan A, et al · · 2024 · cited 5× · PMID 38814827 · DOI 10.1093/sleep/zsae123 -
Adapting and implementing a staff-led sleep intervention in an acute rehabilitation setting.
Ramos BA, Ram K, Martinez M, Sunderrajan A, et al · · 2025 · PMID 40924822 · DOI 10.1177/02692155251375369 -
Sleep Following a Stroke: Multimodal Evaluation of Sleep Health and Disruptions and Impact on Recovery During Acute Inpatient Rehabilitation.
Sindorf J, Campagnini S, O'Brien MK, Sunderrajan A, et al · · 2025 · PMID 40326398 · DOI 10.1177/15459683251335332
Verify or expand the search:
- PubMed search for NCT04254484
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04254484 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Chicago
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04254484.
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