NCT04253600

Understanding the Predictive Factors and the Neurocognitive Basis of Developmental Language Disorder

Status unknown NA Last updated 5 February 2020

What this trial tests

NA trial testing Risk profile screening questionnaire in Developmental Language Disorders in 1,500 participants. Status unknown.

Timeline

1 April 2020

Primary endpoint
1 August 2022

31 August 2024

Quick facts

Lead sponsor	Université Catholique de Louvain
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	1,500
Start date	1 April 2020
Primary completion	1 August 2022
Estimated completion	31 August 2024
Sites	2 locations across Belgium

Drugs / interventions tested

• Risk profile screening questionnaire
• Investigation of the neural correlates of DLD using Magnetic Resonance Imagery (MRI)
• Online investigation of predictive factors associated with DLD and LANCOM app development
• Individual behavioral and cognitive assessment
• Automated analysis of language development and environment

Conditions studied

• Developmental Language Disorders — all drugs for Developmental Language Disorders →
• Language Development — all drugs for Language Development →

Sponsor

Université Catholique de Louvain — full company profile →

Who can join

Under 18 Months, any sex, with Developmental Language Disorders or Language Development. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For most children, language acquisition might appear like an effortless phenomenon, mostly arising from informal daily interaction with their surrounding people. Despite an adequate learning environment however, some children encounter major difficulties in learning their native tongue and develop a Developmental Language Disorder (DLD). Although the existence of a multi-factorial etiology has seemed to reach an agreement, presumably combining genetic and environmental factors to some kind of neural disruption, the underlying mechanisms leading to DLD are, to date, poorly understood.

Many studies have attempted to identify risk factors and early predictors associated with the future development of a language impairment. However, despite the constant efforts to identify early markers able to differentiate between transient and persistent language difficulties, early detection of children who will be developing a DLD remains highly difficult, partially due to the lack of direct and ecological measures of early language and communication development. In addition research on the causal neural correlates of DLD is in its infancy, and often compromised by small sample sizes or analyses methods that lack anatomical specificity to determine the neural correlates of language impairment.

Hence, In order to improve early detection and, therefore, language intervention, this longitudinal research project aims at investigating the early predictive factors as well as the neurocognitive basis of DLD by means of an integrative, multi-dimensional, and multi-methodological approach. To substantially gain insight, this research ideally integrates risk factors at multiple different levels, including the cognitive, neurobiological, parental and environmental level. From a methodological perspective, we will combine direct and indirect behavioral methods with neuroimaging methods in order to propose an early predictive model of language development.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.