NCT04253470 (PE) is a clinical trial of embryo transfer in Progesterone, sponsored by Istituto Clinico Humanitas.

Who is sponsoring NCT04253470?

NCT04253470 is sponsored by Istituto Clinico Humanitas.

What drugs are being tested in NCT04253470?

Interventions in NCT04253470: embryo transfer.

What condition does NCT04253470 study?

NCT04253470 studies Progesterone, ART, Female Infertility, Embryo Transfer.

Is NCT04253470 still recruiting?

NCT04253470 is currently completed. Last updated 5 February 2020.

Last reviewed 2020-02-05 · How we verify

NCT04253470: PE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Debate on Progesterone Elevation on the Day of Triggering

Completed Last updated 5 February 2020

What this trial tests

trial testing embryo transfer in Progesterone in 8,000 participants. Completed in 1 October 2019.

Timeline

1 January 2012

Primary endpoint
31 December 2016

1 October 2019

Quick facts

Lead sponsor	Istituto Clinico Humanitas
Status	Completed
Study type	OBSERVATIONAL
Enrollment	8,000
Start date	1 January 2012
Primary completion	31 December 2016
Estimated completion	1 October 2019
Sites	1 location across Italy

Drugs / interventions tested

embryo transfer

Conditions studied

Progesterone — all drugs for Progesterone →
ART — all drugs for ART →
Female Infertility — all drugs for Female Infertility →
Embryo Transfer — all drugs for Embryo Transfer →

Sponsor

Istituto Clinico Humanitas

Who can join

Adults 18 to 45, female only, with Progesterone or ART. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology. This is a single-center retrospective cohort study. Study duration period is from January 2012 to December 2016. All fresh embryo transfer (ET) both at cleavage stage and blastocyst stage, performed in Humanitas Fertility Center during the study period, were included.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Role of hCG Triggering Progesterone Levels: A Real-World Retrospective Cohort Study of More Than 8000 IVF/ICSI Cycles.
De Cesare R, Morenghi E, Cirillo F, Ronchetti C, et al · · 2020 · cited 13× · PMID 33071968 · DOI 10.3389/fendo.2020.547684

Verify or expand the search:

Other trials of embryo transfer

Trials testing the same drug.

NCT05148624 — Immediate Ambulation Versus Short-time Bed Rest in Sub-fertile Women Undergoing Embryo Transfer · NA · completed
NCT03798886 — Success Rate Natural Cycles Versus Modified Natural Cycles in Frozen Embryos · unknown

Other recruiting trials for Progesterone

Currently open trials in the same condition.

NCT07248046 — Smartphone vs Manual Interpretation of Biomarkers for Ovulation and Luteal Phase Detection (SMOM Study) · recruiting
NCT06928844 — Role of Low Dose Injectable Progesterone in Triggering Ovulation · NA · recruiting

Other Istituto Clinico Humanitas trials

Trials by the same sponsor.

NCT06944288 — Microbiota as Early Diagnostic and predictivE Factor for Osteoarthritic Degeneration and Microbial Contamination · NA · not yet recruiting
NCT07358247 — Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction · not yet recruiting
NCT07362342 — RIght VEntricle Response to Major Lung Resection in VATS and Robotic Surgery · not yet recruiting
NCT07346274 — Intra-operative Hypotension and Post-operative Lactate Level After Pancreatic-duodenectomy. · enrolling by invitation
NCT07491419 — The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome (ACT-FAST) · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04253470 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istituto Clinico Humanitas
Last refreshed: 5 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04253470.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing