NCT04247464 (CHEMOFAST) is a NA clinical trial of Fasting in Fasting, sponsored by IMDEA Food.

Who is sponsoring NCT04247464?

NCT04247464 is sponsored by IMDEA Food.

What drugs are being tested in NCT04247464?

Interventions in NCT04247464: Fasting.

Is NCT04247464 still recruiting?

NCT04247464 is currently completed. Last updated 5 October 2023.

Last reviewed 2023-10-05 · How we verify

NCT04247464: CHEMOFAST

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Short-term Fasting as an Enhancer of Chemotherapy: Pilot Clinical Study on Colorectal Carcinoma Patients

Completed NA Last updated 5 October 2023

What this trial tests

NA trial testing Fasting in Fasting in 11 participants. Completed in 1 February 2023.

Timeline

23 September 2020

Primary endpoint
1 February 2023

1 February 2023

Quick facts

Lead sponsor	IMDEA Food
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	11
Start date	23 September 2020
Primary completion	1 February 2023
Estimated completion	1 February 2023
Sites	1 location across Spain

Drugs / interventions tested

Fasting

Conditions studied

Fasting — all drugs for Fasting →

Sponsor

IMDEA Food

Who can join

Adults 18 to 75, any sex, with Fasting. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will evaluate the ability of short-term fasting to reduce chemotherapy toxicity and enhance anti-tumour response in patients with colorectal carcinoma subjected to chemotherapy.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications.
Zhong X, He X, Wang Y, Hu Z, et al · · 2022 · cited 223× · PMID 36319992 · DOI 10.1186/s13045-022-01358-5
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential.
Xiao YL, Gong Y, Qi YJ, Shao ZM, et al · · 2024 · cited 120× · PMID 38462638 · DOI 10.1038/s41392-024-01771-x
Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer.
Montégut L, de Cabo R, Zitvogel L, Kroemer G. · · 2022 · cited 32× · PMID 35997502 · DOI 10.1158/2159-8290.cd-22-0504
Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy.
Eriau E, Paillet J, Kroemer G, Pol JG. · · 2021 · cited 21× · PMID 33809187 · DOI 10.3390/cancers13061260
Prognostic and Therapeutic Role of CD15 and CD15s in Cancer.
Szlasa W, Wilk K, Knecht-Gurwin K, Gurwin A, et al · · 2022 · cited 15× · PMID 35565333 · DOI 10.3390/cancers14092203
Short-term fasting and fasting mimicking diets combined with chemotherapy: a narrative review.
Kikomeko J, Schutte T, van Velzen MJM, Seefat R, et al · · 2023 · cited 10× · PMID 36970110 · DOI 10.1177/17588359231161418
Impact of ketogenic and fast-mimicking diet in gastrointestinal cancer treatment.
Colombo E, Righini M, Balendra V, Rustamli K, et al · · 2025 · cited 1× · PMID 41278264 · DOI 10.3389/fonc.2025.1677509

Verify or expand the search:

Other trials of Fasting

Trials testing the same drug.

NCT07216989 — Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting · recruiting
NCT06826924 — 7-Days Water-Only Fasting Trial in Prostate Cancer · NA · recruiting
NCT07009288 — A Study of Time-Restricted Eating in Childhood Cancer Survivors · NA · recruiting
NCT06963437 — Interventions for Weight Regain After Bariatric Surgery · NA · completed
NCT07178106 — Investigation of the Relationship Between Peripheral and Central Metabolic Changes Caused by Fasting · NA · completed

Other recruiting trials for Fasting

Currently open trials in the same condition.

NCT07216989 — Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting · recruiting
NCT06737224 — The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active A · NA · recruiting
NCT06779201 — Fasting Effects on Metabolism and Immunity Study in Human · NA · recruiting
NCT06420739 — The Semaglutide Study · active not recruiting
NCT06878781 — Postprandial Metabolome and Metabolic Flexibility · NA · recruiting

Other IMDEA Food trials

Trials by the same sponsor.

NCT06857929 — "Improving Health and Reducing Chronic Disease Risk in Middle-Aged Adults Through Nutrition" · NA · recruiting
NCT06888570 — Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With · enrolling by invitation
NCT07456267 — Plant miRNAs In Human Plasma After Broccoli Consumption · NA · completed
NCT07496320 — Critical Food Ingredients on Immunocompetence to Prevent the Risk and Development of Obesity/Metabolic Syndrome · NA · completed
NCT06392828 — EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04247464 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by IMDEA Food
Last refreshed: 5 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04247464.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing