NCT04243889 is a NA clinical trial of NEOX Cord 1K in Spina Bifida, sponsored by The University of Texas Health Science Center, Houston.

Who is sponsoring NCT04243889?

NCT04243889 is sponsored by The University of Texas Health Science Center, Houston.

What drugs are being tested in NCT04243889?

Interventions in NCT04243889: NEOX Cord 1K.

What condition does NCT04243889 study?

NCT04243889 studies Spina Bifida, Myelomeningocele, Myeloschisis.

Is NCT04243889 still recruiting?

NCT04243889 is currently active, enrolled. Last updated 3 September 2025.

Last reviewed 2025-09-03 · How we verify

NCT04243889

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Fetoscopic NEOX Cord 1K® Spina Bifida Repair

Active, enrolled NA Last updated 3 September 2025

What this trial tests

NA trial testing NEOX Cord 1K in Spina Bifida in 50 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

28 August 2020

Primary endpoint
30 May 2023

12 March 2029

Quick facts

Lead sponsor	The University of Texas Health Science Center, Houston
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	28 August 2020
Primary completion	30 May 2023
Estimated completion	12 March 2029
Sites	1 location across United States

Drugs / interventions tested

NEOX Cord 1K

Conditions studied

Spina Bifida — all drugs for Spina Bifida →
Myelomeningocele — all drugs for Myelomeningocele →
Myeloschisis — all drugs for Myeloschisis →

Sponsor

The University of Texas Health Science Center, Houston

Who can join

18 and older, any sex, with Spina Bifida or Myelomeningocele. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To fetoscopically use cryopreserved human umbilical cord allografts, named NEOX Cord 1K®, as a spinal cord cover of spina bifida defects. This procedure will be performed to create a watertight seal covering over the spinal cord in order to decrease the incidence rates of postnatal morbidities. For larger skin defects, NEOX Cord 1K® may be used as a skin cover.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Fetoscopic Myelomeningocele (MMC) Repair: Evolution of the Technique and a Call for Standardization.
Cruz SM, Hameedi S, Sbragia L, Ogunleye O, et al · · 2025 · cited 2× · PMID 40094785 · DOI 10.3390/jcm14051402
Evolution and Variations of the Ovine Model of Spina Bifida.
Lee SY, Du Y, Hassan AS, Brown E, et al · · 2023 · cited 1× · PMID 37393899 · DOI 10.1159/000531750
Morphometric analysis of spina bifida after fetal repair shows new subtypes with associated outcomes.
Mann LK, Pandiri S, Agarwal N, Northrup H, et al · · 2025 · PMID 40848293 · DOI 10.1002/uog.70035

Verify or expand the search:

Other recruiting trials for Spina Bifida

Currently open trials in the same condition.

NCT06723951 — QUALAS Validation in Dutch · recruiting
NCT06041334 — Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up · NA · recruiting
NCT06802770 — Evaluation of Depression and Anxiety Levels of Parents of Children with Spina Bifida · active not recruiting
NCT05726591 — Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Dis · NA · recruiting
NCT05339932 — Grand Valley State University (GVSU) Skills on Wheels · NA · active not recruiting

Other The University of Texas Health Science Center, Houston trials

Trials by the same sponsor.

NCT04200729 — Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-cente · Phase 4 · not yet recruiting
NCT07225062 — Improving HIV Prevention and Substance Use Post-Sexual Assault Services · NA · not yet recruiting
NCT07396974 — Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT) · NA · not yet recruiting
NCT07170163 — Navigating the Transition to Adulthood: A Dual Language Mobile App for Latino Youth With ASD and Their Families · NA · not yet recruiting
NCT06915441 — Lipid Infusions to Optimize Nutrition Trial · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04243889 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Texas Health Science Center, Houston
Last refreshed: 3 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04243889.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing