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NCT04242251: SPARKLE2
Novel Palliative Care Model for Advanced Cancer Patients: A Randomized Controlled Trial Study
NA trial testing SPARKLE Model of care in Cancer in 239 participants. Completed in 31 January 2024.
30 April 2023
Quick facts
| Lead sponsor | National Cancer Centre, Singapore |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 239 |
| Start date | 8 February 2021 |
| Primary completion | 30 April 2023 |
| Estimated completion | 31 January 2024 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- SPARKLE Model of care
Conditions studied
- Cancer — all drugs for Cancer →
Sponsor
National Cancer Centre, Singapore
Who can join
Adults 21 to 120, any sex, with Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a randomized controlled trial of the 'Supportive and Palliative care Review Kit in Locations Everywhere' (SPARKLE) intervention, an outpatient-based model of early palliative care. The SPARKLE intervention comprises regular symptom monitoring using questionnaires, early identification and prompt treatment of problems identified. Proactive screening for problems facilitates earlier palliative care interventions for advanced cancer patients, whenever needs arise.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Proactive symptom monitoring to initiate timely palliative care for patients with advanced cancer: a randomized controlled trial.
Yang GM, Ke Y, Ng XH, Neo PSH, et al · · 2025 · PMID 40038129 · DOI 10.1007/s00520-025-09311-1 -
Proactive symptom monitoring to initiate timely palliative care for patients with advanced cancer: a randomized controlled trial
YANG GM, KE Y, NG XH, NEO PSH, et al · · 2024 · DOI 10.21203/rs.3.rs-4995145/v1
Verify or expand the search:
- PubMed search for NCT04242251
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04242251 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Cancer Centre, Singapore
- Last refreshed: 3 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04242251.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing