NCT04241289 is a clinical trial in Silent Stroke, sponsored by Population Health Research Institute.

Who is sponsoring NCT04241289?

NCT04241289 is sponsored by Population Health Research Institute.

What condition does NCT04241289 study?

NCT04241289 studies Silent Stroke, Cognitive Decline.

Is NCT04241289 still recruiting?

NCT04241289 is currently completed. Last updated 28 March 2023.

Last reviewed 2023-03-28 · How we verify

NCT04241289

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Detection and Neurological Impact of Cerebrovascular Events in Cardiac Surgery Patients

Completed Last updated 28 March 2023

What this trial tests

trial in Silent Stroke in 66 participants. Completed in 30 September 2018.

Timeline

27 March 2017

Primary endpoint
25 June 2018

30 September 2018

Quick facts

Lead sponsor	Population Health Research Institute
Status	Completed
Study type	OBSERVATIONAL
Enrollment	66
Start date	27 March 2017
Primary completion	25 June 2018
Estimated completion	30 September 2018
Sites	1 location across Canada

Conditions studied

Silent Stroke — all drugs for Silent Stroke →
Cognitive Decline — all drugs for Cognitive Decline →

Sponsor

Population Health Research Institute

Who can join

21 and older, any sex, with Silent Stroke or Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators conducted a prospective observational pilot study to explore the incidence of peri-operative covert strokes (detected by brain MRI) and the potential impact on delirium and cognitive decline in post-operative cardiac surgery patients at the Hamilton General Hospital. This pilot study assessed the feasibility of a larger prospective international cohort study exploring this objective.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Perioperative covert stroke in patients undergoing coronary artery bypass graft surgery.
Browne A, Spence J, Power P, Copland I, et al · · 2020 · cited 7× · PMID 36004290 · DOI 10.1016/j.xjon.2020.08.008
Feasibility of studying the association between intraoperative regional cerebral oxygen saturation and postoperative functional decline (ReFUNCTION): a pilot sub-study of NeuroVISION-Cardiac Surgery.
Spence J, Lamy A, Bosch J, Thabane L, et al · · 2020 · cited 1× · PMID 32767054 · DOI 10.1007/s12630-020-01777-3

Verify or expand the search:

Other recruiting trials for Silent Stroke

Currently open trials in the same condition.

NCT06545786 — Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis · recruiting
NCT04808778 — Stroke Prevention in Young Adults With Sickle Cell Anemia · active not recruiting
NCT04449523 — Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions · recruiting
NCT05685069 — Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions · recruiting

Other Population Health Research Institute trials

Trials by the same sponsor.

NCT07511543 — Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy · Phase 2 · not yet recruiting
NCT07468448 — Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe · Phase 3 · not yet recruiting
NCT06587737 — Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage · Phase 3 · not yet recruiting
NCT07011095 — DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial · EARLY_PHASE1 · not yet recruiting
NCT06508164 — International CRDS Registry · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04241289 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Population Health Research Institute
Last refreshed: 28 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04241289.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing