NCT04238273

High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure for Respiratory Support of Preterm Neonates

Completed Last updated 23 January 2020

What this trial tests

trial testing Functional Echocardiography in Respiratory Distress Syndrome, Newborn in 123 participants. Completed in 1 January 2020.

Timeline

31 January 2018

Primary endpoint
30 November 2019

1 January 2020

Quick facts

Lead sponsor	Ain Shams University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	123
Start date	31 January 2018
Primary completion	30 November 2019
Estimated completion	1 January 2020
Sites	1 location across Egypt

Drugs / interventions tested

• Functional Echocardiography

Conditions studied

• Respiratory Distress Syndrome, Newborn — all drugs for Respiratory Distress Syndrome, Newborn →

Sponsor

Ain Shams University

Who can join

Under 4 Weeks, any sex, with Respiratory Distress Syndrome, Newborn. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This work is designed to:

1. Evaluate the efficacy of HHHFNC in comparison with nCPAP in preterm neonates.
2. Investigate hemodynamic changes associated with HHHFNC in comparison to nCPAP in preterm neonates during periods of non-invasive respiratory support and after being off support.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Hemodynamic changes in preterm neonates with respiratory distress syndrome: high-flow nasal cannula versus nasal continuous positive airway pressure-a randomized controlled trial.
   El-Farrash RA, Shinkar DM, Awad HA, Soliman NM, et al · · 2026 · PMID 42243499 · DOI 10.1038/s41390-026-05127-9