Who is sponsoring NCT04231890?

NCT04231890 is sponsored by Rush University Medical Center.

What drugs are being tested in NCT04231890?

Interventions in NCT04231890: IPI monitoring.

What condition does NCT04231890 study?

NCT04231890 studies Mechanical Ventilation Complication, Extubation.

Is NCT04231890 still recruiting?

NCT04231890 is currently completed. Last updated 8 April 2021.

Last reviewed 2021-04-08 · How we verify

NCT04231890: IPI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Early Identification and Prevention of Extubation Failure in Adults Using Integrated Pulmonary Index

Completed NA Last updated 8 April 2021

What this trial tests

NA trial testing IPI monitoring in Mechanical Ventilation Complication in 174 participants. Completed in 1 April 2021.

Timeline

9 March 2020

Primary endpoint
1 April 2021

1 April 2021

Quick facts

Lead sponsor	Rush University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	174
Start date	9 March 2020
Primary completion	1 April 2021
Estimated completion	1 April 2021
Sites	1 location across United States

Drugs / interventions tested

IPI monitoring

Conditions studied

Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →
Extubation — all drugs for Extubation →

Sponsor

Rush University Medical Center

Who can join

18 and older, any sex, with Mechanical Ventilation Complication or Extubation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary aim of this study is to compare reintubation rate when using standard medical therapy (SMT) versus a monitoring tool, Integrated Pulmonary Index (IPI), to alert clinicians of the patient's respiratory status and need for therapy after planned extubation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Identification and Prevention of Extubation Failure by Using an Automated Continuous Monitoring Alert Versus Standard Care.
Kaur R, Vines DL, Harnois LJ, Elshafei A, et al · · 2022 · cited 5× · PMID 35347080 · DOI 10.4187/respcare.09860

Verify or expand the search:

Other recruiting trials for Mechanical Ventilation Complication

Currently open trials in the same condition.

NCT06921655 — Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation · NA · recruiting
NCT07207772 — EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery · NA · recruiting
NCT07182851 — Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units · recruiting
NCT06575530 — Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients · Phase 4 · recruiting
NCT06592144 — TESTO-TRIAL: Use of Testosterone in Critically Ill Patients · Phase 4 · active not recruiting

Other Rush University Medical Center trials

Trials by the same sponsor.

NCT07278076 — Clinical Decision-Making During FEES: The Impact of Residue Amount and Location · NA · not yet recruiting
NCT07088120 — PRECISION-CPR: PRecision-Controlled Ventilation in CPR · NA · not yet recruiting
NCT06894719 — Oral Tranexamic Acid After Total Knee Arthroplasty · Phase 4 · not yet recruiting
NCT06229392 — A Study to Evaluate the Intratumoral Influenza Vaccine Administration in Patients With Breast Cancer · Phase 1 · withdrawn
NCT07452406 — Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04231890 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rush University Medical Center
Last refreshed: 8 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04231890.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing