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NCT04228315
Biomarkers of P. Vivax Relapse
NA trial testing Primaquine in Malaria in 100 participants. Status unknown.
30 June 2021
Quick facts
| Lead sponsor | Armed Forces Research Institute of Medical Sciences, Thailand |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 19 November 2019 |
| Primary completion | 30 June 2021 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across Thailand |
Drugs / interventions tested
- Primaquine — full drug profile →
Conditions studied
- Malaria — all drugs for Malaria →
- Vivax Malaria — all drugs for Vivax Malaria →
- Relapse — all drugs for Relapse →
- CYP2D6 Polymorphism — all drugs for CYP2D6 Polymorphism →
Sponsor
Armed Forces Research Institute of Medical Sciences, Thailand
Who can join
18 and older, any sex, with Malaria or Vivax Malaria. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Plasmodium vivax malaria is difficult to manage because even after taking medicine that kills the infection in the blood, it can continue to hide quietly in the liver, later re-emerging into the blood and causing another episode of malaria illness (relapse). This clinical trial aims to enroll patient with P. vivax infections and try to detect signals in blood, urine and/or saliva coming from the silent liver stages to help identify who could benefit from treatment with primaquine. It also will explore if certain factors of patients negatively impact primaquine efficacy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04228315
- Europe PMC full search
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Related trials
Other trials of Primaquine
Trials testing the same drug.
- NCT06666491 — An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken · Phase 3 · recruiting
- NCT06191458 — Postpartum Primaquine in Breast Milk · Phase 4 · completed
- NCT06148792 — A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria · Phase 3 · recruiting
- NCT06294912 — A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003) · Phase 1 · completed
- NCT04984759 — Tafenoquine and Primaquine in Colostrum and Breast Milk · Phase 4 · withdrawn
Other recruiting trials for Malaria
Currently open trials in the same condition.
- NCT07358910 — Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective · recruiting
- NCT07036159 — A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 Months · Phase 2 · recruiting
- NCT06735209 — First-in-Human PfSPZ-LARC2 Vaccination/CHMI · Phase 1 · active not recruiting
- NCT06854042 — A Study of Oral E1018 in Healthy Adult Participants · Phase 1 · recruiting
- NCT06607003 — Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Cha · Phase 1 · recruiting
Other Armed Forces Research Institute of Medical Sciences, Thailand trials
Trials by the same sponsor.
- NCT03726593 — Drug Combinations of Atovaquone-Proguanil (AP) With ACT · Phase 4 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04228315 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Armed Forces Research Institute of Medical Sciences, Thailand
- Last refreshed: 14 January 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04228315.
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