Who is sponsoring ACTOS?

ACTOS is sponsored by University Hospital, Antwerp.

What condition does ACTOS study?

ACTOS studies Obstructive Sleep Apnea.

What drugs are being tested in ACTOS?

Interventions: Acetazolamide, Placebo.

What is the status of ACTOS?

ACTOS is currently ACTIVE_NOT_RECRUITING.

Last reviewed 2024-06-17 · How we verify

Acetazolamide as add-on Therapy to Obstructive Sleep Apnea Surgery (ACTOS): a Parallel-group, Double-blind, Placebo-controlled, Randomized Trial

NCT04227093 Phase 4 ACTIVE_NOT_RECRUITING

Surgical procedures are routinely performed as an alternative to continuous positive airway pressure treatment in patients with obstructive sleep apnea (OSA). However, the response to surgery is often variable. Instability of the respiratory control during sleep (or high loop gain) has been associated with poor surgical results in previous research. Acetazolamide (AZM), a carbonic anhydrase inhibitor, has shown potential in reducing loop gain without affecting other physiological OSA traits. In this protocol the investigators will evaluate the clinical efficacy of AZM add-on therapy to surgical procedures in patients with OSA.

Details

Lead sponsor	University Hospital, Antwerp
Phase	Phase 4
Status	ACTIVE_NOT_RECRUITING
Enrolment	26
Start date	2020-01-22
Completion	2024-08

Conditions

Obstructive Sleep Apnea

Interventions

Acetazolamide
Placebo

Primary outcomes

Apnea-hypopnea index (AHI) — 10 weeks of add-on therapy
Change in AHI (events/h) from baseline to follow-up. The AHI is an index of sleep apnea severity that encompasses the frequency of apneas (cessations in breathing) and hypopneas (reductions in airflow).

Countries

Belgium