NCT04226144

Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients

Terminated NA Last updated 4 April 2023

What this trial tests

NA trial testing Breath Stacking Group in Amyotrophic Lateral Sclerosis in 50 participants. Terminated before completion.

Timeline

6 January 2020

Primary endpoint
31 August 2021

1 December 2022

Quick facts

Lead sponsor	Escola Superior de Ciencias da Saude
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	50
Start date	6 January 2020
Primary completion	31 August 2021
Estimated completion	1 December 2022
Sites	1 location across Brazil

Drugs / interventions tested

• Breath Stacking Group
• Breath stacking and EMT

Conditions studied

• Amyotrophic Lateral Sclerosis — all drugs for Amyotrophic Lateral Sclerosis →
• Neuromuscular Diseases — all drugs for Neuromuscular Diseases →

Sponsor

Escola Superior de Ciencias da Saude

Who can join

18 and older, any sex, with Amyotrophic Lateral Sclerosis or Neuromuscular Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

it will be conducted a randomized parallel controlled trial with patients diagnosed with Amyotrophic Lateral Sclerosis (ALS) to compare two techniques to lung recruitment and cough augmentation, to assess their effects on pulmonary function, global functionally, swallowing and ability to speech in these population.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. A pilot study of the breath stacking technique associated with respiratory muscle endurance training in patients with amyotrophic lateral sclerosis: videofluoroscopic findings in the upper airway.
   Dorça A, Sarmet M, Rocha EMSS, Marra MB, et al · · 2021 · cited 4× · PMID 34196381 · DOI 10.5603/arm.a2021.0045
2. Comparison between breath stacking technique associated with expiratory muscle training and breath stacking technique in amyotrophic lateral sclerosis patients: Protocol for randomized single blind trial.
   Dorça A, Alcântara LA, Diniz DS, Sarmet M, et al · · 2020 · cited 4× · PMID 33005816 · DOI 10.1016/j.conctc.2020.100647