NCT04225702 is a clinical trial in Elective Surgery, sponsored by Xuzhou Medical University.

Who is sponsoring NCT04225702?

NCT04225702 is sponsored by Xuzhou Medical University.

What condition does NCT04225702 study?

NCT04225702 studies Elective Surgery, Postoperative Cognitive Dysfunction, Knee Arthroplasty.

Is NCT04225702 still recruiting?

NCT04225702 is currently status unknown. Last updated 13 January 2020.

Last reviewed 2020-01-13 · How we verify

NCT04225702

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty

Status unknown Last updated 13 January 2020

What this trial tests

trial in Elective Surgery in 220 participants. Status unknown.

Timeline

1 January 2020

Primary endpoint
30 June 2020

30 June 2020

Quick facts

Lead sponsor	Xuzhou Medical University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	220
Start date	1 January 2020
Primary completion	30 June 2020
Estimated completion	30 June 2020
Sites	1 location across China

Conditions studied

Elective Surgery — all drugs for Elective Surgery →
Postoperative Cognitive Dysfunction — all drugs for Postoperative Cognitive Dysfunction →
Knee Arthroplasty — all drugs for Knee Arthroplasty →

Sponsor

Xuzhou Medical University

Who can join

60 and older, any sex, with Elective Surgery or Postoperative Cognitive Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2. In this population, knee replacement is the most common, effective, and cost-effective method in all treatments with reducing pain, improving joint function and quality of life. Postoperative cognitive dysfunction (POCD) is a common complication in the elderly, and its incidence can reach 25-40% in major non-cardiac surgery. As for POCD can prolong hospital stay, increase mortality and morbidity, and increase social and economic burden, it is especially important for the prevention and treatment of POCD. However, The mechanism of POCD is still unclear. Studies suggest that it may involve inflammation and oxidative stress in the central nervous system. But for the elderly, they are in a state of low inflammatory response. At the same time, surgery and tourniquets also can trigger or aggravate inflammatory response. Once the inflammatory factors released into the blood circulation, they can act on the central nervous system in a variety of ways. As a result,elderly patients are more likely to develop POCD. In addition, some studies have shown that pain can also increase cognitive burden. Aspirin, its pharmacodynamic effects includes anti-inflammatory and analgesic effects which may have a certain effect on the prevention of POCD.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Elective Surgery

Currently open trials in the same condition.

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Other Xuzhou Medical University trials

Trials by the same sponsor.

NCT07370064 — Clinical Study of Anti-CLL1-CD33-NKG2D Bicephali CAR-T for Relapsed/Refractory Acute Myeloid Leukemia · Phase 1, PHASE2 · not yet recruiting
NCT07280793 — CAR-T Cell Efficacy With Molecular Imaging in Multiple Myeloma · EARLY_PHASE1 · not yet recruiting
NCT07070960 — A Study of Anti-BCMA CAR-T Therapy in Newly Diagnosed Myeloma Patients Who Are Transplant-ineligible · NA · not yet recruiting
NCT07070934 — CAR-T vs. Auto-SCT: Which Works Better for New Myeloma Patients? · Phase 2 · not yet recruiting
NCT06963866 — Comparing ASCT Followed by Anti-BCMA CAR-T vs. ASCT Alone in NDMM Patients Eligible for ASCT · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04225702 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Xuzhou Medical University
Last refreshed: 13 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04225702.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing