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NCT04223180

Rehabilomics Study in Stroke Patients After Robotic Rehabilitation

Completed Last updated 23 February 2021
What this trial tests

trial testing Robotic assisted intervention in Stroke in 50 participants. Completed in 31 January 2021.

Timeline
20 January 2020
Primary endpoint
31 January 2021
31 January 2021

Quick facts

Lead sponsorFondazione Don Carlo Gnocchi Onlus
StatusCompleted
Study typeOBSERVATIONAL
Enrollment50
Start date20 January 2020
Primary completion31 January 2021
Estimated completion31 January 2021
Sites1 location across Italy

Drugs / interventions tested

Conditions studied

Sponsor

Fondazione Don Carlo Gnocchi Onlus — full company profile →

Who can join

Adults 55 to 85, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stroke is associated with disability and impaired quality of life. Persistent motor impairment is common with incomplete recovery of motor function after rehabilitation, mainly in the upper limbs (UL). Robot-mediated therapy (RMT) has been proposed as a viable approach for the rehabilitation of the UL, but more rigorous studies are needed to tailor rehabilitation and to better address the treatment. Brain-derived neurotrophic factor (BDNF) and the serotonin transporter gene (SLC6A4) have been shown to play an important role in post-stroke recovery. After ischemic stroke, disruption and subsequent reorganization of functional brain connections occur both locally and far from the lesion, with the latter possibly contributing to function recovery. This project aims to assess whether epigenetic and genetic variations of BDNF and SLC6A4 can occur in stroke patients after robotic rehabilitation treatment. This study will allow to identify potential genetic and epigenetic biomarkers in post-stroke rehabilitation that could be used to predict the response to a specific rehabilitation treatment and to choose the optimal treatment for the patient (Rehabilomics).

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Oxidative Stress Status in Post Stroke Patients: Sex Differences.
    Siotto M, Germanotta M, Santoro M, Canali R, et al · · 2022 · cited 17× · PMID 35628006 · DOI 10.3390/healthcare10050869
  2. BDNF rs6265 Polymorphism and Its Methylation in Patients with Stroke Undergoing Rehabilitation.
    Santoro M, Siotto M, Germanotta M, Bray E, et al · · 2020 · cited 16× · PMID 33182716 · DOI 10.3390/ijms21228438
  3. Serotonin Levels and Cognitive Recovery in Patients with Subacute Stroke after Rehabilitation Treatment.
    Siotto M, Germanotta M, Santoro M, Cipollini V, et al · · 2021 · cited 10× · PMID 34063444 · DOI 10.3390/brainsci11050642
  4. Association Study of <i>SLC6A4</i> (5-HTTLPR) Polymorphism and Its Promoter Methylation with Rehabilitation Outcome in Patients with Subacute Stroke.
    Santoro M, Siotto M, Germanotta M, Mastrorosa A, et al · · 2021 · cited 8× · PMID 33923526 · DOI 10.3390/genes12040579

Verify or expand the search:

Other trials of Robotic assisted intervention

Trials testing the same drug.

Other recruiting trials for Stroke

Currently open trials in the same condition.

Other Fondazione Don Carlo Gnocchi Onlus trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04223180.

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