Who is sponsoring NCT04221594?

NCT04221594 is sponsored by Emory University.

What drugs are being tested in NCT04221594?

Interventions in NCT04221594: Invasive Cardiac Catheterization (ICA), Coronary Computed Tomographic Angiogram (CCTA), Dynamic Cardiac Positron Emission Tomography (dPET).

What condition does NCT04221594 study?

NCT04221594 studies Coronary Artery Disease.

Is NCT04221594 still recruiting?

NCT04221594 is currently completed. Last updated 2 October 2023.

Last reviewed 2023-10-02 · How we verify

NCT04221594

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery

Completed Last updated 2 October 2023

What this trial tests

trial testing Invasive Cardiac Catheterization (ICA) in Coronary Artery Disease in 68 participants. Completed in 30 June 2023.

Timeline

1 November 2019

Primary endpoint
30 June 2023

30 June 2023

Quick facts

Lead sponsor	Emory University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	68
Start date	1 November 2019
Primary completion	30 June 2023
Estimated completion	30 June 2023
Sites	6 locations across United States, South Korea

Drugs / interventions tested

Invasive Cardiac Catheterization (ICA)
Coronary Computed Tomographic Angiogram (CCTA)
Dynamic Cardiac Positron Emission Tomography (dPET)

Conditions studied

Coronary Artery Disease — all drugs for Coronary Artery Disease →

Sponsor

Emory University

Who can join

18 and older, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This observational prospective clinical study is to develop software tools to fuse coronary anatomy data obtained from CT coronary angiography with dynamic PET data to noninvasively measure absolute myocardial blood flow, flow reserve and relative flow reserve across specific coronary lesions. Results will be compared to those obtained invasively in the catheterization laboratory.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Rationale and design of the quantification of myocardial blood flow using dynamic PET/CTA-fused imagery (DEMYSTIFY) to determine physiological significance of specific coronary lesions.
AlBadri A, Piccinelli M, Cho SG, Lee JM, et al · · 2020 · cited 7× · PMID 32026327 · DOI 10.1007/s12350-020-02052-0
Clinically viable myocardial CCTA segmentation for measuring vessel-specific myocardial blood flow from dynamic PET/CCTA hybrid fusion.
Piccinelli M, Dahiya N, Nye JA, Folks R, et al · · 2022 · cited 3× · PMID 35165793 · DOI 10.1186/s41824-021-00122-1

Verify or expand the search:

Other recruiting trials for Coronary Artery Disease

Currently open trials in the same condition.

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Other Emory University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04221594 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Emory University
Last refreshed: 2 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04221594.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing