NCT04220697 is a NA clinical trial of electroencephalography (EEG) in Thoracotomy, sponsored by Université Catholique de Louvain.

Who is sponsoring NCT04220697?

NCT04220697 is sponsored by Université Catholique de Louvain.

What drugs are being tested in NCT04220697?

Interventions in NCT04220697: electroencephalography (EEG), questionnaires, high frequency electrical stimulation of the forearm skin (HFS), cutaneous mechanical pinprick stimulation.

What condition does NCT04220697 study?

NCT04220697 studies Thoracotomy, Hyperalgesia, Hyperalgesia, Secondary, Central Sensitisation, Electroencephalography, Persistent Postsurgical Pain, Humans.

Is NCT04220697 still recruiting?

NCT04220697 is currently status unknown. Last updated 6 October 2021.

Last reviewed 2021-10-06 · How we verify

NCT04220697

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Central Sensitisation and Postoperative Pain

Status unknown NA Last updated 6 October 2021

What this trial tests

NA trial testing electroencephalography (EEG) in Thoracotomy in 70 participants. Status unknown.

Timeline

29 January 2020

Primary endpoint
30 September 2022

31 December 2022

Quick facts

Lead sponsor	Université Catholique de Louvain
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	screening
Enrollment	70
Start date	29 January 2020
Primary completion	30 September 2022
Estimated completion	31 December 2022
Sites	2 locations across Belgium

Drugs / interventions tested

electroencephalography (EEG)
questionnaires
high frequency electrical stimulation of the forearm skin (HFS)
cutaneous mechanical pinprick stimulation

Conditions studied

Thoracotomy — all drugs for Thoracotomy →
Hyperalgesia — all drugs for Hyperalgesia →
Hyperalgesia, Secondary — all drugs for Hyperalgesia, Secondary →
Central Sensitisation — all drugs for Central Sensitisation →

Sponsor

Université Catholique de Louvain — full company profile →

Who can join

Adults 18 to 80, any sex, with Thoracotomy or Hyperalgesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

One out of 10 patients undergoing surgery develops persistent post-surgical pain (PPSP). Unfortunately, available therapies for treating this pain have limited success. It is therefore of great importance to find strategies to prevent PPSP. The goal of this project is to find new screening tools that identify patients that are at risk for developing PPSP. Tissue injury and inflammation following surgery increase the excitability of spinal nociceptive neurons ("central sensitisation", CS) with pain hypersensitivity as consequence. It is thought that CS plays an important role in persistent pain. The first objective of this project is to assess in human patients if the propensity to develop CS manifested as secondary hyperalgesia before surgery is predictive for PPSP. In addition, we will test if the frequency content of the resting-state EEG reflecting the initial state of the brain will be related to the propensity for developing CS and to the presence of PPSP at two months after surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Preoperative susceptibility to developing secondary hyperalgesia is associated with post-thoracotomy pain at 2 months.
Gousset S, Cappe M, Lenoir C, Steyaert A, et al · · 2025 · cited 6× · PMID 39651902 · DOI 10.1002/ejp.4768

Verify or expand the search:

Other trials of electroencephalography (EEG)

Trials testing the same drug.

NCT03209323 — Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol · NA · completed

Other recruiting trials for Thoracotomy

Currently open trials in the same condition.

NCT07424638 — Interscalene Block Versus Anterior Suprascapular Block for Post-Thoracotomy Shoulder Pain · NA · recruiting
NCT07367581 — Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer · NA · recruiting
NCT06930183 — Awake Thoracic Epidural Anesthesia Versus General Anesthesia in Thoracotomy · NA · recruiting
NCT06330168 — Paravertebral Calcitonin in Thoracotomy · NA · active not recruiting
NCT05600569 — Registry of the Spanish Society of Thoracic Surgery · recruiting

Other Université Catholique de Louvain trials

Trials by the same sponsor.

NCT07453524 — Assessing Chronic Pain Patient Preferences · NA · not yet recruiting
NCT07422909 — Bridging the Gap: Implementing BRIDGES · NA · not yet recruiting
NCT07420231 — Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort · NA · not yet recruiting
NCT07360223 — Internalized Symptoms in Adolescents With Autism Spectrum Disorder (ASD) and Typically Developing Adolescents : Gaining · not yet recruiting
NCT07263971 — Birth Experience of Women Giving Birth in Belgium · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04220697 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Université Catholique de Louvain
Last refreshed: 6 October 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04220697.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing