NCT04220645 (Opportuni-C) is a NA clinical trial of Opportunstic treatment in Hepatitis C, sponsored by University Hospital, Akershus.

Who is sponsoring NCT04220645?

NCT04220645 is sponsored by University Hospital, Akershus.

What drugs are being tested in NCT04220645?

Interventions in NCT04220645: Opportunstic treatment, Standard of care.

What condition does NCT04220645 study?

NCT04220645 studies Hepatitis C, Substance Use Disorders.

Is NCT04220645 still recruiting?

NCT04220645 is currently completed. Last updated 8 December 2022.

Last reviewed 2022-12-08 · How we verify

NCT04220645: Opportuni-C

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Opportunstic Hepatitis C Virus Treatment

Completed NA Last updated 8 December 2022

What this trial tests

NA trial testing Opportunstic treatment in Hepatitis C in 218 participants. Completed in 30 June 2022.

Timeline

1 October 2019

Primary endpoint
31 December 2021

30 June 2022

Quick facts

Lead sponsor	University Hospital, Akershus
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	218
Start date	1 October 2019
Primary completion	31 December 2021
Estimated completion	30 June 2022
Sites	1 location across Norway

Drugs / interventions tested

Opportunstic treatment
Standard of care

Conditions studied

Hepatitis C — all drugs for Hepatitis C →
Substance Use Disorders — all drugs for Substance Use Disorders →

Sponsor

University Hospital, Akershus

Who can join

18 and older, any sex, with Hepatitis C or Substance Use Disorders. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The project will assess the effect of opportunistically treating hepatitis C virus (HCV) infection immediately when HCV-infected people who inject drugs are hospitalized for acute care in psychiatric, interdisciplinary specialized drug treatment or somatic wards. We will compare this approach with the current standard of care (SOC), which is referral to the outpatient clinic at the medical department following discharge.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Opportunistic Treatment of Hepatitis C Infection Among Hospitalized People Who Inject Drugs (OPPORTUNI-C): A Stepped Wedge Cluster Randomized Trial.
Midgard H, Malme KB, Pihl CM, Berg-Pedersen RM, et al · · 2024 · cited 19× · PMID 37992203 · DOI 10.1093/cid/ciad711
Opportunistic treatment of hepatitis C virus infection (OPPORTUNI-C): study protocol for a pragmatic stepped wedge cluster randomized trial of immediate versus outpatient treatment initiation among hospitalized people who inject drugs.
Midgard H, Finbråten AK, Malme KB, Berg-Pedersen RM, et al · · 2020 · cited 6× · PMID 32539853 · DOI 10.1186/s13063-020-04434-8
Virologic Response and Reinfection Following HCV Treatment among Hospitalized People Who Inject Drugs: Follow-Up Data from the OPPORTUNI-C Trial.
Malme KB, Stene-Johansen K, Klundby I, Backe Ø, et al · · 2024 · cited 4× · PMID 38932151 · DOI 10.3390/v16060858

Verify or expand the search:

Other recruiting trials for Hepatitis C

Currently open trials in the same condition.

NCT06263829 — HCV Tappt Adherence Study · NA · recruiting
NCT06179498 — Partner Navigation Intervention for Hepatitis C Treatment Among Young People Who Inject Drugs · NA · recruiting
NCT06367465 — Feasibility and Acceptability of HCV Treatment in Pregnancy · recruiting
NCT05668780 — Buprenorphine Integration Research and Community Health · NA · active not recruiting
NCT05208697 — Tele-Harm Reduction · NA · active not recruiting

Other University Hospital, Akershus trials

Trials by the same sponsor.

NCT06865027 — The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenbu · NA · enrolling by invitation
NCT06721754 — Diabetes Related Foot Ulcers with Negative Pressure Wound Therapy · NA · recruiting
NCT06731985 — The Follow-up After Shorter Tapes Study. Effectiveness and Safety of Shorter Trans-obturator Tapes. · recruiting
NCT06576752 — Management of Patients with Heart Failure At Home After Hospital Discharge · NA · recruiting
NCT06032715 — Brief Intervention for Sleep Medication Misuse Among Elderly · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04220645 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Akershus
Last refreshed: 8 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04220645.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing