Who is sponsoring NCT04218903?

NCT04218903 is sponsored by Hospital de Clinicas de Porto Alegre.

What drugs are being tested in NCT04218903?

Interventions in NCT04218903: Combined training performed four times per week (CT4), Combined training performed two times per week (CT2).

What condition does NCT04218903 study?

NCT04218903 studies Hypertension, Cardiovascular Risk Factor, Cardiovascular Diseases.

Is NCT04218903 still recruiting?

NCT04218903 is currently completed. Last updated 24 April 2025.

Last reviewed 2025-04-24 · How we verify

NCT04218903: RADAH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Resistance Plus Aerobic Training Using Different Weekly Frequencies And Hypertension

Completed NA Last updated 24 April 2025

What this trial tests

NA trial testing Combined training performed four times per week (CT4) in Hypertension in 98 participants. Completed in 31 March 2025.

Timeline

1 March 2022

Primary endpoint
31 December 2024

31 March 2025

Quick facts

Lead sponsor	Hospital de Clinicas de Porto Alegre
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	98
Start date	1 March 2022
Primary completion	31 December 2024
Estimated completion	31 March 2025
Sites	1 location across Brazil

Drugs / interventions tested

Combined training performed four times per week (CT4)
Combined training performed two times per week (CT2)

Conditions studied

Hypertension — all drugs for Hypertension →
Cardiovascular Risk Factor — all drugs for Cardiovascular Risk Factor →
Cardiovascular Diseases — all drugs for Cardiovascular Diseases →

Sponsor

Hospital de Clinicas de Porto Alegre

Who can join

Adults 50 to 80, any sex, with Hypertension or Cardiovascular Risk Factor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Combined training is a cornerstone intervention to improve functionality and to reduce blood pressure in older adults with hypertension. Acute blood pressure lowering after exercise seems to predict the extent of blood pressure reduction after chronic training interventions. Based on that, the same weekly amount of exercise performed more frequently could be more beneficial to blood pressure management. The aim of the present study is to evaluate the effects of a combined exercise program performed four versus two times per week on 24-h ambulatory blood pressure and other cardiovascular risk factors in older individuals with hypertension.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of combined training performed two or four times per week on 24-h blood pressure, glycosylated hemoglobin and other health-related outcomes in aging individuals with hypertension: Rationale and study protocol of a randomized clinical trial.
Ferrari R, Domingues LB, Carpes LO, Frank PA, et al · · 2021 · cited 6× · PMID 34038410 · DOI 10.1371/journal.pone.0251654
Differential Effects of Twice vs. Four Times Weekly Combined Exercise Training in Aging Adults With Hypertension: A Randomized Clinical Trial
Ferrari R, Schneider V, Domingues L, Abreu R, et al · · 2026
Differential Effects of Twice vs. Four Times Weekly Combined Exercise Training in Aging Adults With Hypertension: A Randomized Clinical Trial.
Ferrari R, Schneider VM, Domingues LB, Abreu R, et al · · 2026 · PMID 41792948 · DOI 10.1111/sms.70239

Verify or expand the search:

Other recruiting trials for Hypertension

Currently open trials in the same condition.

NCT07413159 — The "Check, Monitor, Control Hypertension" Study is a 24-month Randomized Trial in Houston Targeting African Americans A · NA · recruiting
NCT07361276 — Observational Study That Will Evaluate Treatment Patterns in the Management of Hypertension in the Public Primary Care S · recruiting
NCT07238556 — A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors · NA · recruiting
NCT07238400 — Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia · Phase 2 · recruiting
NCT07135505 — Early Time-Restricted Eating in Older Adults With Hypertension · NA · recruiting

Other Hospital de Clinicas de Porto Alegre trials

Trials by the same sponsor.

NCT07469722 — POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure · Phase 2, PHASE3 · not yet recruiting
NCT07264179 — Tracheal Cuff Pressure and Postoperative Complications: A Prospective Observational Study. · not yet recruiting
NCT07052058 — Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to · Phase 2 · not yet recruiting
NCT06953128 — General Versus Regional Anesthesia in Peripheral Arterial Surgery · NA · not yet recruiting
NCT06934707 — Meal Frequency and Glycemic Control in Individuals With Type 1 Diabetes · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04218903 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital de Clinicas de Porto Alegre
Last refreshed: 24 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04218903.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing