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NCT04218500
The Effectiveness and Safety of Niacinamide 4% and Virgin Coconut Oil 30% for Secondary Prevention of Occupational Hand Dermatitis
NA trial testing Niacinamide 4% in Contact Dermatitis of Hands in 92 participants. Completed in 31 December 2019.
15 October 2019
Quick facts
| Lead sponsor | Indonesia University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 92 |
| Start date | 3 September 2019 |
| Primary completion | 15 October 2019 |
| Estimated completion | 31 December 2019 |
| Sites | 1 location across Indonesia |
Drugs / interventions tested
- Niacinamide 4%
- Virgin Coconut oil 30%
Conditions studied
- Contact Dermatitis of Hands — all drugs for Contact Dermatitis of Hands →
Sponsor
Indonesia University
Who can join
Adults 18 to 58, any sex, with Contact Dermatitis of Hands. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Occupational hand dermatitis (OHD) often occurs in intensive care unit (ICU) nurses, especially in individuals who are vulnerable due to irritant exposure e.g. hand rub alcohol and repeated hand washing activities. The use of moisturizer is one of the recommendations for skin care in OHD. Niacinamide which has anti-inflammatory effects and can improve the skin barrier function. Virgin coconut oil (VCO) is rich in lipids and lauric acid, and has an occlusive effect. Until now there are no guidelines and reference types of moisturizers for secondary prevention in DTAK.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
NAD<sup>+</sup> metabolism: pathophysiologic mechanisms and therapeutic potential.
Xie N, Zhang L, Gao W, Huang C, et al · · 2020 · cited 744× · PMID 33028824 · DOI 10.1038/s41392-020-00311-7 -
Clinical Measurement of Transepidermal Water Loss.
Kundu D, Jayaraman A, Sen CK. · · 2026 · cited 4× · PMID 40476522 · DOI 10.1089/wound.2024.0148 -
Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond.
Camillo L, Zavattaro E, Savoia P. · · 2025 · cited 4× · PMID 40005371 · DOI 10.3390/medicina61020254
Verify or expand the search:
- PubMed search for NCT04218500
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04218500 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Indonesia University
- Last refreshed: 6 January 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04218500.
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