NCT04214990 (EASTERN) is a Phase 3 clinical trial of Aspirin 100mg in Aspirin, sponsored by National Cancer Center, Korea.

Who is sponsoring NCT04214990?

NCT04214990 is sponsored by National Cancer Center, Korea.

What drugs are being tested in NCT04214990?

Interventions in NCT04214990: Aspirin 100mg, Placebo oral tablet.

What condition does NCT04214990 study?

NCT04214990 studies Aspirin, Gastric Cancer.

Is NCT04214990 still recruiting?

NCT04214990 is currently recruiting now. Last updated 27 December 2024.

Last reviewed 2024-12-27 · How we verify

NCT04214990: EASTERN

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients

Recruiting now Phase 3 Last updated 27 December 2024

What this trial tests

Phase 3 trial testing Aspirin 100mg in Aspirin in 1,700 participants. Currently enrolling.

Timeline

15 February 2020

Primary endpoint
31 March 2031

31 March 2032

Quick facts

Lead sponsor	National Cancer Center, Korea
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	1,700
Start date	15 February 2020
Primary completion	31 March 2031
Estimated completion	31 March 2032
Sites	10 locations across South Korea

Drugs / interventions tested

Aspirin 100mg — full drug profile →
Placebo oral tablet — full drug profile →

Conditions studied

Aspirin — all drugs for Aspirin →
Gastric Cancer — all drugs for Gastric Cancer →

Sponsor

National Cancer Center, Korea

Who can join

Adults 19 to 70, any sex, with Aspirin or Gastric Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aimed to investigate the effect of low-dose (100 mg) asprin on the prevention of gastric cancer in the early gastric cancer patients with negative H. pylori status who underwent endoscopic submucosal dissection.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Inflammation and tumor progression: signaling pathways and targeted intervention.
Zhao H, Wu L, Yan G, Chen Y, et al · · 2021 · cited 1932× · PMID 34248142 · DOI 10.1038/s41392-021-00658-5
Tumor biomarkers for diagnosis, prognosis and targeted therapy.
Zhou Y, Tao L, Qiu J, Xu J, et al · · 2024 · cited 379× · PMID 38763973 · DOI 10.1038/s41392-024-01823-2
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions.
Fu L, Jin W, Zhang J, Zhu L, et al · · 2022 · cited 47× · PMID 35256933 · DOI 10.1016/j.apsb.2021.09.006
Emerging Role of Neutrophil Extracellular Traps in Gastrointestinal Tumors: A Narrative Review.
Zhang Y, Song J, Zhang Y, Li T, et al · · 2022 · cited 12× · PMID 36613779 · DOI 10.3390/ijms24010334
Repurposing Drugs for Cancer Prevention: Targeting Mechanisms Common to Chronic Diseases.
Choradia N, Szabo E. · · 2024 · cited 1× · PMID 39312454 · DOI 10.1097/ppo.0000000000000746

Verify or expand the search:

Other trials of Aspirin 100mg

Trials testing the same drug.

NCT06580223 — Aspirin or Rivaroxaban Thromboprophylaxis for Patients With Multiple Myeloma · Phase 3 · not yet recruiting
NCT06952712 — Aspirin 150 mg vs 100 mg for Prevention of Preeclampsia in High-Risk Obese Pregnant Women · Phase 3 · not yet recruiting
NCT06417411 — LEARNER- Low dosE AspiRiN prEterm tRial (Angola) · Phase 1, PHASE2 · recruiting
NCT05960721 — Low-dose NOAC Versus GDMT After LAAO · NA · recruiting
NCT05257824 — Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling · Phase 4 · completed

Other recruiting trials for Aspirin

Currently open trials in the same condition.

NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
NCT07125417 — Non-antithrombotic Versus. Single Antiplatelet Therapy Following Left Atrial Appendage Closure · Phase 4 · recruiting
NCT06882850 — Immunomodulation During Pregnancy · recruiting
NCT06185621 — The Effect of Aspirin on Recurrent Acute Pancreatitis · NA · recruiting
NCT05802940 — Low Dose Aspirin Alerts in High-Risk Pregnancies · NA · active not recruiting

Other National Cancer Center, Korea trials

Trials by the same sponsor.

NCT07399561 — Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy · NA · not yet recruiting
NCT07121478 — Patients With High-grade Pancreatic Neuroendocrine Tumors · Phase 2 · enrolling by invitation
NCT07171528 — Secondary Cytoreductive Surgery After Chemotherapy for Recurrent Epithelial Ovarian Cancer · Phase 2 · recruiting
NCT07125924 — Intravesical Hyaluronic Acid (HA) for Preventing Radiation Cystitis on Bladder Cancer · NA · not yet recruiting
NCT07041515 — Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04214990 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Cancer Center, Korea
Last refreshed: 27 December 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04214990.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing