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NCT04213950
Improving Adherence to Rabies PEP Guideline Recommendations
NA trial testing Rabies PEP quality improvement bundle in Rabies in 70 participants. Completed in 23 December 2020.
23 December 2020
Quick facts
| Lead sponsor | The Methodist Hospital Research Institute |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 70 |
| Start date | 29 December 2019 |
| Primary completion | 23 December 2020 |
| Estimated completion | 23 December 2020 |
| Sites | 15 locations across United States |
Drugs / interventions tested
- Rabies PEP quality improvement bundle
Conditions studied
- Rabies — all drugs for Rabies →
- Rabies Human — all drugs for Rabies Human →
- Rabies Virus Infection — all drugs for Rabies Virus Infection →
Sponsor
The Methodist Hospital Research Institute
Who can join
Eligibility, any sex, with Rabies or Rabies Human. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This quasi-experimental, quality improvement study will be conducted across the Houston Methodist system, including all hospital-based and freestanding emergency departments (ED). Previous research identified opportunities to improve patient selection and delivery of rabies immune globulin (IG) as recommended by Centers for Disease Control and Prevention (CDC) guideline recommendations for rabies postexposure prophylaxis (PEP). The purpose of this study is to develop, implement, and measure the impact of a quality improvement bundle that consists of (1) rabies PEP electronic health records (EHR) enhancements, (2) education to ED staff, and (3) education to patients. Adherence to quality indicators, which are based on CDC guideline recommendations, for patient selection and delivery of rabies IG for 12 months following implementation (post-implementation group) will be compared with a historical control group.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Implementation of Clinical Decision Support on Emergency Department Delivery of Human Rabies Immune Globulin.
Yuan F, Iso T, Rizk E, Saldana RB, et al · · 2022 · cited 3× · PMID 35727583 · DOI 10.1001/jamanetworkopen.2022.16631
Verify or expand the search:
- PubMed search for NCT04213950
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Rabies
Currently open trials in the same condition.
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- NCT07021703 — A Clinical Trial of Rabies Vaccine（Human Diploid Cell）for Human Use,Freeze-dried · Phase 1 · recruiting
- NCT06998004 — A Trial to Evaluate the Safety and Immunogenicity of an Investigational Vaccine for the Prevention of Yellow Fever, and · Phase 1 · recruiting
Other The Methodist Hospital Research Institute trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04213950 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Methodist Hospital Research Institute
- Last refreshed: 5 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04213950.
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