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NCT04208802
Effect of Smoking on Saliva Composition and the Development of Dental Erosion
trial testing Use of fluoridated toothpaste in Dental Erosion in 50 participants. Completed in 29 July 2022.
29 July 2022
Quick facts
| Lead sponsor | University of Göttingen |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 24 September 2020 |
| Primary completion | 29 July 2022 |
| Estimated completion | 29 July 2022 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Use of fluoridated toothpaste
- Wearing of an intraoral device with bovine tooth samples
- Wearing of an intraoral device with resin samples
Conditions studied
- Dental Erosion — all drugs for Dental Erosion →
Sponsor
University of Göttingen
Who can join
Adults 20 to 50, any sex, with Dental Erosion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion. Healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. Afterwards, specimens are eroded extraorally and calcium release into the acid is measured. Total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. Additionally, salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04208802
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Related trials
Other trials of Use of fluoridated toothpaste
Trials testing the same drug.
- NCT04914208 — Effect of Wearing Face Masks on Salivary Parameters and Halitosis · NA · completed
Other University of Göttingen trials
Trials by the same sponsor.
- NCT06982417 — InsightRP2 Registry · recruiting
- NCT06441058 — Retrospective Database Study: Influence of Post-endodontic Restoration Placement on Survival of Root Canal-treated Teeth · completed
- NCT06129799 — Exercise CMR in (p)LF-LG AS · recruiting
- NCT05335616 — Behavioral Change Simulation Experiment Regarding Dentists' Repair Behavior · NA · completed
- NCT04914208 — Effect of Wearing Face Masks on Salivary Parameters and Halitosis · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04208802 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Göttingen
- Last refreshed: 27 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04208802.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing