Efficacy of Ivabradine Versus Propranolol Premedication During Hypotensive Anesthesia in Endoscopic Sinus Surgery

NCT04208594 NA UNKNOWN

50 Patients, aged from 18 to 39 years, ASA physical status I and II, undergoing endoscopic sinus surgery will be enrolled in the study.The patients will be randomly allocated by simple randomization using a computer programme into two groups by closed envelope technique (having 25 patients in each group): GROUP (P): will receive oral propranolol (INDERAL® -propranolol hydrochloride Ph. Eur. 10mg manufactured by AstraZeneca Egypt under license of AstraZeneca UK), 10 mg one tablet at 8:00 pm in the evening before the day of the surgery and one 10 mg tablet one hour before the induction of anesthesia. GROUP (I): will receive oral ivabradine (Procoralan® 5mg manufactured by Servier laboratories, France), 5 mg one tablet at 8:00 pm in the evening before the day of the surgery and one 5 mg tablet one hour before the induction of anesthesia.

Details

Lead sponsor	Alexandria University
Phase	NA
Status	UNKNOWN
Enrolment	50
Start date	2019-12-11
Completion	2020-05

Conditions

• Ivabradine
• Propranolol
• Hypotensive Anesthesia

Interventions

• Ivabradine
• Propranolol

Primary outcomes

• Hemodynamic changes : — Baseline before induction of anesthesia. - Every 30 min throughout deliberate hypotension till termination of NTG infusion. - 5 minutes after the end of deliberate hypote
  Mean arterial blood pressure (MABP) in mmHg by invasive monitoring using GE monitor . • Heart rate: (beats / minute
• amount of Blood loss — the procedure time
  Intraoperative bleeding

Countries

Egypt