Last reviewed · How we verify
NCT04202432: PP3D
Clinical Validation of Algorithms for Mean Systemic Filling Pressure and Automated Cardiac Output
trial testing Mean systemic filling pressure in Shock, Cardiogenic in 18 participants. Completed in 30 August 2019.
30 August 2019
Quick facts
| Lead sponsor | Catharina Ziekenhuis Eindhoven |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 18 |
| Start date | 24 June 2019 |
| Primary completion | 30 August 2019 |
| Estimated completion | 30 August 2019 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Mean systemic filling pressure
Conditions studied
- Shock, Cardiogenic — all drugs for Shock, Cardiogenic →
- Shock Hypovolemic — all drugs for Shock Hypovolemic →
- Hypovolemia — all drugs for Hypovolemia →
- Cardiac Failure — all drugs for Cardiac Failure →
Sponsor
Catharina Ziekenhuis Eindhoven — full company profile →
Who can join
18 and older, any sex, with Shock, Cardiogenic or Shock Hypovolemic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prospective combined clinical validation of an algorithmic calculated mean systemic filling pressure (Pms-Nav) with the gold standard for Pms (Pms calculated from venous return curves during inspiratory hold procedures with incremental airway pressures; Pms-Insp). Secondary correlation between invasive cardiac output measurement versus 3D TOE and carotid echo doppler measured cardiac output.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical validation of a computerized algorithm to determine mean systemic filling pressure.
Meijs LPB, van Houte J, Conjaerts BCM, Bindels AJGH, et al · · 2022 · cited 20× · PMID 33791920 · DOI 10.1007/s10877-020-00636-2 -
Evaluating corrected carotid flow time as a non-invasive parameter for trending cardiac output and stroke volume in cardiac surgery patients.
van Houte J, Raaijmaakers AE, Mooi FJ, Meijs LPB, et al · · 2023 · cited 13× · PMID 35397758 · DOI 10.1007/s40477-022-00678-z
Verify or expand the search:
- PubMed search for NCT04202432
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Shock, Cardiogenic
Currently open trials in the same condition.
- NCT06832722 — Procizumab (PCZ; AK1967) in Critical Cardiovascular Care · Phase 1, PHASE2 · recruiting
- NCT07085221 — Digital Out-of-hospital Management on Clinical Outcomes in Patients With Early Cardiogenic Shock · NA · recruiting
- NCT06766006 — ECMO LEft Ventricle UNloading Strategy · recruiting
- NCT05669183 — Hemodynamic Comparison of Peripheral and Central VA ECMO. · recruiting
Other Catharina Ziekenhuis Eindhoven trials
Trials by the same sponsor.
- NCT07314138 — Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronar · NA · not yet recruiting
- NCT06768060 — Mindfulness-based Intervention Prior to External Cephalic Version · NA · recruiting
- NCT06574867 — Evaluation of the viQtor Monitoring Solution on Surgical Wards · recruiting
- NCT06374836 — The Contractile Response of the Thoracic Aorta to Vasoactive Substances · completed
- NCT06401291 — Transcutaneous Electrical Nerve Stimulation in Patients With Angina and Non-Obstructive Coronary Arteries · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04202432 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Catharina Ziekenhuis Eindhoven
- Last refreshed: 18 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04202432.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing