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NCT04201912
Role of TLR2 and TLR4 in Stage 2 Periodontitis Patients
NA trial testing saliva analysis for Toll like receptor activity in Periodontal Inflammation in 60 participants. Completed in 1 September 2019.
1 August 2019
Quick facts
| Lead sponsor | Ajman University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 60 |
| Start date | 1 May 2019 |
| Primary completion | 1 August 2019 |
| Estimated completion | 1 September 2019 |
| Sites | 1 location across United Arab Emirates |
Drugs / interventions tested
- saliva analysis for Toll like receptor activity
Conditions studied
- Periodontal Inflammation — all drugs for Periodontal Inflammation →
Sponsor
Ajman University
Who can join
Adults 18 to 70, any sex, with Periodontal Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In Health, mucosal inflammation is prevented by TLR (Toll like receptors) that interact with Specific MAMP (microbe associated molecular pattern). Currently about 13TLRs have been identified. Among them, TLR2 and 4 recognize most organisms . Periodontal disease is mixed infection resulting due to dysbiosis . When aggravated by systemic disease the role of TLRs is detrimental for the overall state of periodontal apparatus. Type 2 diabetes is one of the systemic disease which is seen a risk factor if uncontrolled can exaggerate the titer of TLR2 and TLR4 biomarkers . Various studies have been evaluated to determine the role of TLRs in autoimmune and periodontal conditions. The purpose of this study is to determine if both TLR2 and TLR4 play equal roles in periodontal disease and in cases where periodontal disease is complicated by the presence of systemic disease. Individual role of TLR2 and TLR4 in active disease will help determine treatment strategies and will also be able to predict potential biomarker in disease.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Application of the In Vitro HoxB8 Model System to Characterize the Contributions of Neutrophil-LPS Interaction to Periodontal Disease.
Sochalska M, Stańczyk MB, Użarowska M, Zubrzycka N, et al · · 2020 · cited 4× · PMID 32630208 · DOI 10.3390/pathogens9070530
Verify or expand the search:
- PubMed search for NCT04201912
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periodontal Inflammation
Currently open trials in the same condition.
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- NCT07013682 — PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal Therapy · NA · recruiting
- NCT07415148 — Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy · NA · active not recruiting
- NCT07536204 — Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis · recruiting
- NCT05864768 — The Role of Diet in Periodontal Inflammation: A Controlled Clinical Study · NA · recruiting
Other Ajman University trials
Trials by the same sponsor.
- NCT07230717 — Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp · NA · not yet recruiting
- NCT06711263 — Role of Herbal Based Mouthwashes in Plaque Control · NA · not yet recruiting
- NCT06554938 — Efficacy of Dental Hygiene Aids in Reducing Gingival Bleeding and Plaque Among Orthodontic Patients. · NA · completed
- NCT06134713 — Effect of Intra-Canal Cryotherapy on Postoperative Pain After Endodontic Procedures · Phase 4 · unknown
- NCT05931705 — Vit D Receptor Gene Polymorphism · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04201912 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ajman University
- Last refreshed: 18 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04201912.
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