NCT04199468 is a Phase 1 clinical trial of Active Delta-9-THC in Cannabis, sponsored by Yale University.

Who is sponsoring NCT04199468?

NCT04199468 is sponsored by Yale University.

What drugs are being tested in NCT04199468?

Interventions in NCT04199468: Active Delta-9-THC, Placebo Delta-9-THC, Active Ketamine, Placebo Ketamine.

What condition does NCT04199468 study?

NCT04199468 studies Cannabis, Ketamine.

Is NCT04199468 still recruiting?

NCT04199468 is currently completed. Last updated 25 March 2024.

Last reviewed 2024-03-25 · How we verify

NCT04199468

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis

Completed Phase 1 Last updated 25 March 2024

What this trial tests

Phase 1 trial testing Active Delta-9-THC in Cannabis in 22 participants. Completed in 21 June 2022.

Timeline

24 September 2019

Primary endpoint
21 June 2022

21 June 2022

Quick facts

Lead sponsor	Yale University
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	22
Start date	24 September 2019
Primary completion	21 June 2022
Estimated completion	21 June 2022
Sites	1 location across United States

Drugs / interventions tested

Active Delta-9-THC — full drug profile →
Placebo Delta-9-THC
Active Ketamine — full drug profile →
Placebo Ketamine

Conditions studied

Cannabis — all drugs for Cannabis →
Ketamine — all drugs for Ketamine →

Sponsor

Yale University

Who can join

Adults 18 to 45, any sex, with Cannabis or Ketamine. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the research protocol is to evaluate cannabinoid-glutamate interactions in humans. As part of this aim the investigators will assess the safety and tolerability of the combination of NMDA antagonist, ketamine, and the cannabinoid, delta-9-tetrahydrocannabinol (THC), in healthy adult subjects, and characterize the interactive effects of ketamine and THC on various electrophysiological (EEG), cognitive, and behavioral outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Use of Psychedelics in the Treatment of Medical Conditions: An Analysis of Currently Registered Psychedelics Studies in the American Drug Trial Registry.
Kurtz JS, Patel NA, Gendreau JL, Yang C, et al · · 2022 · cited 19× · PMID 36259015 · DOI 10.7759/cureus.29167

Verify or expand the search:

Other trials of Active Delta-9-THC

Trials testing the same drug.

NCT04920539 — In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans · Phase 1 · completed

Other recruiting trials for Cannabis

Currently open trials in the same condition.

NCT05999383 — Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration · Phase 2 · recruiting
NCT07417059 — Sex Hormones Impact on Cannabis Response · NA · recruiting
NCT07194018 — Use of Cannabis Oil in Fibromyalgia · active not recruiting
NCT06099379 — Modulation of THC Effects by CBD: a Dose-ranging Study · Phase 1, PHASE2 · recruiting
NCT05742724 — The Pharmacokinetics of Single Dose Oral Tetrahydrocannabinol and Cannabidiol · Phase 1 · active not recruiting

Other Yale University trials

Trials by the same sponsor.

NCT06900998 — Pilot Study: Effects of Nimodipine on Alcohol Drinking · Phase 2 · not yet recruiting
NCT04910984 — Developing a Chatbot to Promote HIV Testing · NA · not yet recruiting
NCT07458087 — Accuracy of the Accuro 3S · NA · not yet recruiting
NCT07398404 — A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Pa · Phase 1, PHASE2 · not yet recruiting
NCT07305324 — Improving Liver Fibrosis Diagnosis in Primary Care Using FibroX AI · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04199468 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yale University
Last refreshed: 25 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04199468.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing