Last reviewed · How we verify
NCT04198987
Dietary Monosaccharide Supplementation in Patients With Congenital Disorders of Glycosylation
trial in Congenital Disorder of Glycosylation in 20 participants. Completed in 11 June 2025.
11 June 2025
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 6 December 2018 |
| Primary completion | 11 June 2025 |
| Estimated completion | 11 June 2025 |
| Sites | 1 location across United States |
Conditions studied
- Congenital Disorder of Glycosylation — all drugs for Congenital Disorder of Glycosylation →
Sponsor
Mayo Clinic
Who can join
Eligibility, any sex, with Congenital Disorder of Glycosylation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Researchers are trying to assess whether the use of simple sugars given as a daily dietary supplement can improve the health of children with congenital disorders of glycosylation (CDG).
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Congenital disorders of glycosylation (CDG): state of the art in 2022.
Francisco R, Brasil S, Poejo J, Jaeken J, et al · · 2023 · cited 34× · PMID 37858231 · DOI 10.1186/s13023-023-02879-z -
Novel insights into the phenotype and long-term D-gal treatment in PGM1-CDG: a case series.
Radenkovic S, Johnsen C, Schulze A, Lail G, et al · · 2023 · cited 7× · PMID 37181075 · DOI 10.1177/26330040221150269 -
A rare cause of infantile achalasia: GMPPA-congenital disorder of glycosylation with two novel compound heterozygous variants.
Geiculescu I, Dranove J, Cosper G, Edmondson AC, et al · · 2022 · cited 7× · PMID 35665995 · DOI 10.1002/ajmg.a.62859 -
A Community-Led Approach as a Guide to Overcome Challenges for Therapy Research in Congenital Disorders of Glycosylation.
Francisco R, Brasil S, Pascoal C, Edmondson AC, et al · · 2022 · cited 5× · PMID 35682409 · DOI 10.3390/ijerph19116829
Verify or expand the search:
- PubMed search for NCT04198987
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04198987 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 1 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04198987.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing