NCT04198194 is a clinical trial of Predictors of events in Prevention, sponsored by Apple Inc..

Who is sponsoring NCT04198194?

NCT04198194 is sponsored by Apple Inc..

What drugs are being tested in NCT04198194?

Interventions in NCT04198194: Predictors of events.

What condition does NCT04198194 study?

NCT04198194 studies Prevention.

Is NCT04198194 still recruiting?

NCT04198194 is currently active, enrolled. Last updated 21 February 2025.

Last reviewed 2025-02-21 · How we verify

NCT04198194

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Apple Heart & Movement Study

Active, enrolled Last updated 21 February 2025

What this trial tests

trial testing Predictors of events in Prevention in 500,000 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

14 November 2019

Primary endpoint
28 February 2025

28 February 2025

Quick facts

Lead sponsor	Apple Inc.
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	500,000
Start date	14 November 2019
Primary completion	28 February 2025
Estimated completion	28 February 2025
Sites	1 location across United States

Drugs / interventions tested

Predictors of events

Conditions studied

Prevention — all drugs for Prevention →

Sponsor

Apple Inc. — full company profile →

Who can join

18 and older, any sex, with Prevention. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will look for factors that affect heart health and potentially cause deterioration in mobility or heart function. Participant's Apple Watch and iPhone can help researchers gain a better understanding of potential early warning signs. This can lead to new interventions and products that will help millions lead longer, healthier, and more active lives.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Pulse oximetry values from 33,080 participants in the Apple Heart & Movement Study.
Shapiro I, Stein J, MacRae C, O'Reilly M. · · 2023 · cited 11× · PMID 37500721 · DOI 10.1038/s41746-023-00851-6
Modeling personalized heart rate response to exercise and environmental factors with wearables data.
Nazaret A, Tonekaboni S, Darnell G, Ren SY, et al · · 2023 · cited 10× · PMID 37968567 · DOI 10.1038/s41746-023-00926-4
Understanding activity and physiology at scale: The Apple Heart & Movement Study.
Truslow J, Spillane A, Lin H, Cyr K, et al · · 2024 · cited 9× · PMID 39256546 · DOI 10.1038/s41746-024-01187-5
A wearable-based aging clock associates with disease and behavior.
Miller AC, Futoma J, Abbaspourazad S, Heinze-Deml C, et al · · 2025 · cited 1× · PMID 41115881 · DOI 10.1038/s41467-025-64275-4
Naturalistic sleep tracking in a longitudinal cohort: Uncertainty and bias in short duration sampling.
Goparaju B, de Palma G, Bianchi MT. · · 2025 · PMID 41183052 · DOI 10.1371/journal.pone.0334950
Deep sleep homeostatic response to naturalistic sleep loss.
Goparaju B, Ravindran S, Bianchi MT. · · 2025 · PMID 41052109 · DOI 10.1371/journal.pdig.0001021

Verify or expand the search:

Other recruiting trials for Prevention

Currently open trials in the same condition.

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Other Apple Inc. trials

Trials by the same sponsor.

NCT05872035 — Smartphone Enabled Hearing Study · NA · completed
NCT05852951 — Cycle and Ovulation Study Expansion · completed
NCT04912180 — Apple Respiratory Study · terminated
NCT04699812 — Atrial Fibrillation Algorithms Clinical Validation Study · NA · completed
NCT04247581 — ECG App Algorithms Clinical Validation Study · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04198194 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Apple Inc.
Last refreshed: 21 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04198194.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing