Last reviewed · How we verify
Dapagliflozin vs Empagliflozin on Flow Mediated Dilation in Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a considered one of the main global health challenges; the vascular endothelium plays an important role in vascular dysfunction in DM; Hyperglycemia induced by it is recognized as the main factor for the development of vascular complications of the disease, secondary to a reduction in nitric oxide production; "flow-mediated dilation" is the most commonly used technique for the evaluation of endothelial function, being the non-invasive method most widely used. It has been reported that with the use of SGLT2 inhibitors the development of cardiovascular complications in patients with T2DM is a decrease, as well the arterial stiffness, endothelial dysfunction and increasing on the shear stress and blood viscosity; and experimentally.
Details
| Lead sponsor | Centro Universitario de Ciencias de la Salud, Mexico |
|---|---|
| Phase | PHASE3 |
| Status | UNKNOWN |
| Enrolment | 24 |
| Start date | Mon Dec 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Dec 30 2020 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Type 2 Diabetes Mellitus
Interventions
- Dapagliflozin Pill
- Empagliflozin Pill
- Placebo pill
Countries
Mexico